The future of prenatal molecular diagnostics: impact of the changing patent landscape.

Pharm Pat Anal

Fox Rothschild LLP, 2000 Market Street 20th Floor, Philadelphia, PA 19103-3222, USA.

Published: January 2014

Download full-text PDF

Source
http://dx.doi.org/10.4155/ppa.13.76DOI Listing

Publication Analysis

Top Keywords

future prenatal
4
prenatal molecular
4
molecular diagnostics
4
diagnostics impact
4
impact changing
4
changing patent
4
patent landscape
4
future
1
molecular
1
diagnostics
1

Similar Publications

Prenatal metal(loid) exposure and preterm birth: a systematic review of the epidemiologic evidence.

J Expo Sci Environ Epidemiol

January 2025

Department of Environmental Sciences & Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background: Preterm birth (PTB) is a common pregnancy complication associated with significant neonatal morbidity. Prenatal exposure to environmental chemicals, including toxic and/or essential metal(loid)s, may contribute to PTB risk.

Objective: We aimed to summarize the epidemiologic evidence of the associations among levels of arsenic (As), cadmium (Cd), chromium (Cr), copper (Cu), mercury (Hg), manganese (Mn), lead (Pb), and zinc (Zn) assessed during the prenatal period and PTB or gestational age at delivery; to assess the quality of the literature and strength of evidence for an effect for each metal; and to provide recommendations for future research.

View Article and Find Full Text PDF

Placental PFAS concentrations are associated with perturbations of placental DNA methylation.

Environ Pollut

January 2025

Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR; Arkansas Children's Nutrition Center, Little Rock, AR.

The placenta is crucial for fetal development, is affected by PFAS toxicity, and evidence is accumulating that gestational PFAS perturb the epigenetic activity of the placenta. Gestational PFAS exposure can adversely affect offspring, yet individual and cumulative impacts of PFAS on the placental epigenome remain underexplored. Here, we conducted an epigenome-wide association study (EWAS) to examine the relationships between placental PFAS levels and DNA methylation in a cohort of mother-infant dyads in Arkansas (N=151).

View Article and Find Full Text PDF

Vitamin D offers numerous under-recognized health benefits beyond its well-known role in musculoskeletal health. It is vital for extra-renal tissues, prenatal health, brain function, immunity, pregnancy, cancer prevention, and cardiovascular health. Existing guidelines issued by governmental and health organizations are bone-centric and largely overlook the abovementioned extra-skeletal benefits and optimal thresholds for vitamin D.

View Article and Find Full Text PDF

Background: Understanding fetal growth is essential for predicting perinatal outcomes and long-term health implications. This study explores the correlation between ultrasound parameters and gestational age in the Minangkabau ethnic group, focusing on the biometric variables biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), femur length (FL), and humerus length (HL) during the second trimester.

Methods: Conducted from December 2020 to December 2021, the research employed a cross-sectional design at the Fetomaternal clinic of Hospital M.

View Article and Find Full Text PDF

Background: Huntington's disease (HD) is a multifaceted neurological disorder characterized by the progressive deterioration of motor, cognitive, and psychiatric functions. Despite a limited understanding of its pathogenesis, research has implicated abnormal trinucleotide cytosine-adenine-guanine CAG repeat expansion in the huntingtin gene (HTT) as a critical factor. The development of innovative strategies is imperative for the early detection of predictive biomarkers, enabling timely intervention and mitigating irreversible cellular damage.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!