Potentiating antitumor immunity with αGC-loaded exosomes.

Oncoimmunology

Translational Immunology Unit; Department of Medicine; Solna, Karolinska Institutet; Stockholm, Sweden.

Published: October 2013

Anticancer immunotherapy is a promising treatment modality since it bears the potential of being highly specific, but effective clinical applications are still under development. We have recently described an exosome-based strategy for co-delivery of α-galactosylceramide and a tumor-associated antigen that synergistically potentiates tumor-specific adaptive immune responses while preventing the anergy of invariant natural killer T (iNKT) cells. We propose that the next generation of exosome-based immunotherapies should involve iNKT-cell ligands to induce a broad, amplified and sustainable antitumor immune response.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862686PMC
http://dx.doi.org/10.4161/onci.26261DOI Listing

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