The fabrication of high-density polymer microarray is described, allowing the simultaneous and efficient evaluation of more than 7000 different polymers in a single-cellular-based screen. These high-density polymer arrays are applied in the search for synthetic substrates for hESCs culture. Up-scaling of the identified hit polymers enables long-term cellular cultivation and promoted successful stem-cell maintenance.
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http://dx.doi.org/10.1002/adhm.201300489 | DOI Listing |
Nat Commun
January 2025
College of Polymer Science and Engineering, West China School of Public Health, Med-X center of materials, Sichuan University, Chengdu, Sichuan, 610065, China.
Chronic kidney disease (CKD) ultimately causes renal fibrosis and end-stage renal disease, thus seriously threatens human health. However, current medications for CKD and fibrosis are inefficient, which is often due to poor targeting capability to renal tubule. In this study, we discover that biomimetic high-density lipoprotein (bHDL) lipid nanoparticles possess excellent targeting ability to injured tubular epithelial cells by kidney injury molecule-1(KIM-1) mediated internalization.
View Article and Find Full Text PDFPolymers (Basel)
January 2025
Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland.
The deformation behavior and instabilities occurring during the drawing of high-density polyethylene (HDPE) were investigated using wide- and small-angle X-ray scattering (WAXS and SAXS) and scanning electron microscopy (SEM) in plain HDPE and paraffin wax- and/or chloroform-modified samples. In contrast to neat HDPE, the modified materials demonstrated strongly suppressed cavitation. However, regardless of cavitation, the tensile deformation of all samples was found to be governed by crystallographic mechanisms active in the crystalline lamellae, supported by shear in the amorphous layers, i.
View Article and Find Full Text PDFPolymers (Basel)
January 2025
School of Engineering, Institute for Materials and Processes, The University of Edinburgh, Sanderson Building, King's Buildings, Edinburgh EH9 3FB, UK.
The phase separation of high-density polyethylene (HDPE)-polypropylene (PP) blends was studied using atomic force microscopy in tapping mode to obtain height and phase images. The results are compared with those from scanning electron microscopy imaging and are connected to the thermomechanical properties of the blends, characterised through differential scanning calorimetry, dynamic mechanical analysis (DMA), and tensile testing. Pure PP, as well as 10:90 and 20:80 weight ratio HDPE-PP blends, showed a homogeneous morphology, but the 25:75 HDPE-PP blends exhibited a sub-micrometre droplet-matrix structure, and the 50:50 HDPE-PP blends displayed a more complex co-continuous nano/microphase-separated structure.
View Article and Find Full Text PDFMaterials (Basel)
January 2025
High Speed 3D Printing Research Center, National Taiwan University of Science and Technology, No. 43, Sec. 4, Keelung Rd., Taipei 106, Taiwan.
Selective laser sintering (SLS) is one of the prominent methods of polymer additive manufacturing (AM). A low-power laser source is used to directly melt and sinter polymer material into the desired shape. This study focuses on the utilization of the low-power laser SLS system to successfully manufacture metallic components through the development of a metal-polymer composite material.
View Article and Find Full Text PDFNano Lett
January 2025
National Laboratory of Solid States Microstructures, School of Physics, Nanjing University, Nanjing 210093, People's Republic of China.
While the highest-performing memristors currently available offer superior storage density and energy efficiency, their large-scale integration is hindered by the random distribution of filaments and nonuniform resistive switching in memory cells. Here, we demonstrate the self-organized synthesis of a type of two-dimensional protonic coordination polymers with high crystallinity and porosity. Hydrogen-bond networks containing proton carriers along its nanochannels enable uniform resistive switching down to the subnanoscale range.
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