Modification of the lysosomalkationic test by V. E. Pigarevsky (1978) is suggested. The method implies usage of 10% neutral formalin (according to Lilly) for the material fixation, optimal staining of histological preparations from gastric and duodenal mucosa with fast green, usage of hematoxyline Carazzi for the additional staining of cellular nuclei. The technique is readily available, it is easily interpreted, is highly informative for studying the inflammatory changes in gastric and duodenal mucosa in gastroduodenal diseases and in the experiments.
Download full-text PDF |
Source |
---|
Introduction: Metabolic and bariatric surgery (MBS) is increasingly used for obesity and metabolic disease, with safety profiles showing it is among the safest major operations. The last 20 + years have noted significantly improved safety that has been accompanied by decreasing length of stay and select populations electing for outpatient surgery, leading to continued decreases in cost. Regardless, readmissions and complications still occur, requiring inpatient postoperative care (IP-POC).
View Article and Find Full Text PDFCureus
December 2024
Gastroenterology, University Hospital Tsaritsa Ioanna, Medical University of Sofia, Sofia, BGR.
Cholecystoenteric fistulas are a rare complication of chronic gallstone disease. If not diagnosed on time, they can cause several complications such as gallstone ileus, gastric outlet obstruction (Bouveret syndrome), cholangitis, or liver abscess. We present a case of a patient with chronic calculous cholecystitis, who was admitted due to unspecific abdominal discomfort and impaired liver function with increased cholestatic liver enzymes.
View Article and Find Full Text PDFPharm Res
January 2025
Department of Pharmaceutics Science, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Purpose: Tylvalosin Tartrate (TAT), a new-generation macrolide antibiotic, undergoes significant degradation in the stomach and in vivo rapid elimination upon oral administration, resulting in poor bioavailability. This study developed TAT enteric amorphous pellets by liquid layering (TAT/EAP-LL) with pH-sensitive and burst release characteristics, to enhance drug stability in the stomach and concentration enrichment in the duodenum.
Methods: The drug loading layer, isolation layer and enteric layer were formed on the surface of the blank core pellets.
Updates Surg
January 2025
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Obesity is a major global health problem and at the same time a financial burden for social security systems. For a long time, conventional lifestyle interventions have tried unsuccessfully to find a solution. It has been proven that only interventions that ultimately address the central control centers of hunger, appetite and satiety will lead to sustained weight loss.
View Article and Find Full Text PDFAm J Physiol Gastrointest Liver Physiol
January 2025
Department of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
The stomach is responsible for physically and chemically processing the ingested meal before controlled emptying into the duodenum through the pyloric sphincter. An incompetent pylorus allows reflux from the duodenum back into the stomach, and if the amount of reflux is large enough, it could alter the low pH environment of the stomach and erode the mucosal lining of the lumen. In some cases, the regurgitated contents can also reach the esophagus leading to additional complications.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!