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Circadian Disruption in Glaucoma: Causes, Consequences, and Countermeasures.
Front Biosci (Landmark Ed)
December 2024
Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN 55455, USA.
This review explores the intricate relationship between glaucoma and circadian rhythm disturbances. As a principal organ for photic signal reception and transduction, the eye plays a pivotal role in coordinating the body's circadian rhythms through specialized retinal ganglion cells (RGCs), particularly intrinsically photosensitive RGCs (ipRGCs). These cells are critical in transmitting light signals to the suprachiasmatic nucleus (SCN), the central circadian clock that synchronizes physiological processes to the 24-hour light-dark cycle.
View Article and Find Full Text PDFHuman Herpesvirus 6A Infection-Associated Acute Anterior Uveitis.
J Inflamm Res
December 2024
Department of Ophthalmology, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310003, People's Republic of China.
Human herpesvirus 6 (HHV-6) infection can cause ophthalmic diseases in immunocompetent patients, recipients of bone marrow transplants, and patients with acquired immunodeficiency syndrome (AIDS). This study describes the case of a healthy 37-year-old male who presented with unilateral anterior uveitis (AU), significant anterior chamber exudation, pupillary membrane closure, increased intraocular pressure, and eyelid edema. Notably, HHV-6A was the only pathogenic agent identified in the blood and aqueous humor.
View Article and Find Full Text PDFIntraluminal Insertion of 9-0 Nylon for Postoperative Choroidal Detachment After Preserflo MicroShunt Implantation: A Case Report.
Cureus
November 2024
Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, JPN.
Preserflo MicroShunt (PMS) implantation is a minimally invasive surgical procedure for treating glaucoma. Postoperative hypotony, a common complication of PMS implantation, can be prevented and treated with 10-0 nylon insertion. In this report, we present a case of postoperative hypotony following PMS implantation that was treated with intraluminal insertion of 9-0 nylon.
View Article and Find Full Text PDFThe role of acetazolamide in critical care and emergency medicine.
J Geriatr Cardiol
November 2024
Geriatric Medicine Residency Program, University of Rome "Tor Vergata", Rome, Italy.
Acetazolamide is the commonly prescribed oral and intravenous carbonic anhydrase inhibitor; over the years, its use in clinical practice has decreased in favor of more recent drugs. However, it is a rather handy drug, which can be useful in several clinical settings when managing critically ill patients. The objective of this review is the evaluation of the most recent evidence on the use of acetazolamide in emergency medicine and critical care medicine.
View Article and Find Full Text PDFGLP-1 RECEPTOR AGONISTS USE AND INCIDENCE OF GLAUCOMA: A SYSTEMATIC REVIEW AND META-ANALYSIS: GLP-1 receptor agonists use and incidence of glaucoma.
Am J Ophthalmol
December 2024
Glaucoma Service, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.
Introduction: In diabetics, glucagon-like peptide 1 (GLP-1) receptor agonists (RA) may protect against microvascular alterations and oxidative stress, both of which have been implicated in glaucoma. Multiple studies suggest a possible relation between GLP-1 RA use and the development of glaucoma. This study performs a systematic review of the literature regarding the incidence of glaucoma development in type 2 diabetes patients treated with GLP-1 receptor agonists compared to a control group.
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