Epigenetic regulation of HIV-1 latency in astrocytes.

J Virol

Department of Immunology/Microbiology, Rush University Medical Center, Chicago, Illinois, USA.

Published: March 2014

HIV infiltrates the brain at early times postinfection and remains latent within astrocytes and macrophages. Because astrocytes are the most abundant cell type in the brain, we evaluated epigenetic regulation of HIV latency in astrocytes. We have shown that class I histone deacetylases (HDACs) and a lysine-specific histone methyltransferase, SU(VAR)3-9, play a significant role in silencing of HIV transcription in astrocytes. Our studies add to a growing body of evidence demonstrating that astrocytes are a reservoir for HIV.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958059PMC
http://dx.doi.org/10.1128/JVI.03333-13DOI Listing

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