Focal Lesion in Splenium of Corpus Callosum on FLAIR MRI: Common Findings in Aged Patients.

Focal high signal intensity in the splenium of the corpus callosum on fluid-attenuated inversion-recovery (FLAIR) images is generally considered an abnormal MR finding. The aim of this study was to determine the frequency of this finding in elderly patients and review the differentiation from other diseases with the similar findings. FLAIR images of 132 patients with suspect CNS disease were retrospectively reviewed. The changes in the splenium of corpus callosum, deep white matter lesions, periventricular matter lesions, infarcts, atrophy and age were analyzed, as well as history. Among the initial 132 patients, focal high signal intensity in the splenium was associated with aging, white matter changes, atrophy, and cognitive disorders. Focal high signal intensity in the splenium of the corpus callosum on FLAIR image is a common finding in elderly patients, especially in aged patients with cognitive disorders. The pathologic alterations were commonly described by the term of "leukoaraiosis". Knowledge of this finding and differentiation from other lesions focusing on the splenium of corpus callosum may help avoid unnecessary invasive diagnostic and therapeutic intervention.