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| http://dx.doi.org/10.1177/193229681300700628 | DOI Listing |
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Anti-obesity pharmacological agents for polycystic ovary syndrome: A systematic review and meta-analysis to inform the 2023 international evidence-based guideline.
Obes Rev
May 2024
NICM Health Research Institute, Western Sydney University, Penrith, New South Wales, Australia.
Article Synopsis
- - This review and meta-analysis assessed the effectiveness of anti-obesity drugs on various health outcomes in women with polycystic ovary syndrome (PCOS), helping to update PCOS treatment guidelines for 2023.
- - Eleven clinical trials were analyzed, revealing that most anti-obesity agents led to improvements in weight-related outcomes, with drugs like liraglutide and semaglutide showing stronger results than placebo.
- - However, the comparative analysis of specific agents showed no significant differences in outcomes between exenatide and metformin, or between orlistat combined with a contraceptive pill and the pill alone, indicating a need for more extensive research on these treatments in PCOS.
Impact of Persistent Medication Adherence and Compliance with Lifestyle Recommendations on Major Cardiovascular Events and One-Year Mortality in Patients with Type 2 Diabetes and Advanced Stages of Atherosclerosis: Results From a Prospective Cohort Study.
Glob Heart
November 2023
Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Background: The aim of this study was to evaluate the impact of single and combined effects of persistent medication adherence and compliance with lifestyle recommendations on the incidence of major adverse cardiovascular events (MACE) and one-year all-cause mortality in patients with type 2 diabetes (T2D) and peripheral artery disease (PAD) after partial foot amputation (PFA), representing a unique cohort of patients with advanced stages of atherosclerosis.
Methods: This is a prospective cohort study of 785 consecutive patients (mean age 60.9 ± 9.
Comparison of hyperoxia or normoxia resolution of intermittent hypoxia and intermittent hyperoxia episodes on liver histopathology, IGF-1, IGFBP-3, and GHBP in neonatal rats.
Growth Horm IGF Res
December 2023
Department of Pediatrics, Division of Neonatal-Perinatal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA; Department of Ophthalmology; State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA. Electronic address:
Objective: Extremely low gestational age neonates requiring oxygen therapy for chronic lung disease experience repeated fluctuations in arterial oxygen saturation, or intermittent hypoxia (IH), during the first few weeks of life. These events are associated with a high risk for reduced growth, hypertension, and insulin resistance in later life. This study tested the hypothesis that IH, or intermittent hyperoxia have similar negative effects on the liver; somatic growth; and liver insulin-like growth factor (IGF)-I, IGF binding protein (BP)-3, and growth hormone binding protein (GHBP), regardless of resolution in normoxia or hyperoxia between episodes.
View Article and Find Full Text PDFCausal relationship between nonalcoholic fatty liver disease and different sleep traits: a bidirectional Mendelian randomized study.
Front Endocrinol (Lausanne)
June 2023
Synopsis of Golden Chamber Department, Chinese Medicine College, Beijing University of Chinese Medicine, Beijing, China.
Background And Aims: Non-alcoholic fatty liver disease(NAFLD) is common worldwide and has previously been reported to be associated with sleep traits. However, it is not clear whether NAFLD changes sleep traits or whether the changes in sleep traits lead to the onset of NAFLD. The purpose of this study was to investigate the causal relationship between NAFLD and changes in sleep traits using Mendelian randomization.
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