Background: Insulin resistance (IR) has known to be associated with coronary artery disease (CAD), but the assessment of severity of the CAD based on IR in type 2 diabetes mellitus has not been established in detail.
Aims: The aim of our study was to establish the correlation between IR and the severity of CAD in type 2 diabetes mellitus.
Materials And Methods: In a cross-sectional study design, 61 consecutive patients with type 2 diabetes mellitus who underwent coronary angiogram for the evaluation of CAD were recruited. Fasting blood glucose, fasting insulin levels, systolic blood pressure and total cholesterol/high density lipoprotein-cholesterol ratio were determined. Homeostasis model assessment-IR (HOMA-IR) was correlated with severity of CAD, which was measured by modified Gensini Score.
Results: There was a significant correlation between log HOMA-IR and severity of CAD (r = 0.303, P = 0.009) in diabetic patients. Correlation of the Gensini Score with other known risk factors was not significant.
Conclusions: The results of our study indicate that we might able to predict the severity of CAD by measure of IR.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842704 | PMC |
| http://dx.doi.org/10.4103/1947-2714.120799 | DOI Listing |
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