Aim: The present research work was aimed to formulate and characterize psoralen-encapsulated cavamax W7 composite ethosomal gel and compare its in vitro and ex vivo behavior against psoralen-cavamax W7-complex reference gel.
Materials And Methods: A total of nine formulations of composite ethosomes were prepared by injection method using 3(2) factorial design and entrapment efficiency was designated as dependent variable. Concomitantly, psoralen was complexed with cavamax W7 (1:1 molar ratio) by kneading method and formation of complex was confirmed by Diffuse reflectance spectroscopy (DRS), scanning electron microscopy (SEM), X-ray diffraction (XRD), and differential scanning calorimetry (DSC).
Results: F9 with vesicle size of 183 ± 2.8 nm, and highest % entrapment efficiency of 98.12 ± 1.15 was selected as optimized formulation. Transmission electron microscopy (TEM) revealed uniform and spherical shaped vesicles. The optimized formulation F9 was formulated as carbapol gel and compared against ethosomal gel, psoralen gel, and psoralen cavamax W7 complex gel. The gels were evaluated for permeation characteristics and the rank order was composite ethosomal gel > ethosomal gel > psoralen-cavamax W7 complex gel > psoralen gel. The ethosomal gel (G5) with highest in vitro permeation of 82.48 ± 2.23% was subjected to in vivo Confocal laser scanning microscopy (CLSM) studies using rhodamine B as tracer. The penetration of rhodamine B was uniform, deeper, and two times faster into epidermis than control gel.
Conclusion: Conclusively, cavamax W7 composite ethosomes present themselves as efficient carrier for superior topical delivery of psoralen and have potential for clinical applications in minimizing side effects associated with photosensitivity of psoralen.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853756 | PMC |
| http://dx.doi.org/10.4103/2230-973X.121284 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Investigation of the whitening activity of ginsenosides from Panax notoginseng and optimization of the dosage form.
J Ginseng Res
November 2024
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China.
Article Synopsis
- Ginsenoside from Panax notoginseng has higher content and potential as a skin whitening agent compared to Panax ginseng, with research focusing on its effectiveness in inhibiting melanin production.* -
- The study utilized zebrafish embryos and B16 cells to identify potent ginsenosides, specifically protopanaxtriol saponins (PTS), which showed strong inhibition of the enzyme tyrosinase, linked to melanin synthesis.* -
- PTS was successfully formulated into a gel using ethosomes, proving effective in reducing UVB-induced tanning in mice, suggesting its potential for safe skin whitening applications.*
Author Correction: Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies.
Sci Rep
October 2024
School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, P.R. China.
Comparative Study on Enhanced Skin Permeation Efficiency of Phenylephrine via Novel Lipid Vesicles: A Promising Approach in Preventing Chemotherapy-Induced Alopecia Management.
Curr Pharm Biotechnol
October 2024
Institute of Pharmaceutical Research, GLA University, Mathura-281406, (UP), India.
Article Synopsis
- Chemotherapy-induced alopecia can negatively affect patients' mental health, and this study explores using Phenylephrine, a topical vasoconstrictor, to potentially reduce hair loss during chemotherapy.
- The research focused on improving the skin permeation and sustained release of Phenylephrine using different lipid vesicles (ethosomes, invasomes, transfersomes) incorporated into hydrogels.
- Findings revealed that ethosomal and invasomal gels significantly improved drug delivery efficiency when compared to traditional gels, indicating their potential effectiveness in targeting local vasculature for sustained vasoconstriction.
Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies.
Sci Rep
October 2024
School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, P.R. China.
Article Synopsis
- The study aimed to develop and test ethosomes containing vitamin D3 to improve treatment for psoriasis, a chronic skin condition.
- The formulations utilized soya lecithin, propylene glycol, and ethanol, achieving high drug encapsulation efficiency (96.25%) and favorable vesicle characteristics (particle sizes of 148-657 nm).
- Stability tests over six months confirmed that the vitamin D3 ethosomal gel is safe for use, maintaining suitable order, pH, and viscosity for patient application.
Formulation and development of frovatriptan succinate in situ gel for nasal drug delivery: In vitro and ex vivo evaluation.
Pak J Pharm Sci
May 2024
Department of Pharmaceutics, College of Pharmacy, University of Baghdad and Uruk University, Iraq.
Magrain is a depleting disease that sometimes requires extensive treatment, ideally with medication that targets the brain, with minimized systemic adverse effects, preferably with a single daily medication; these properties are offered partially by the current dosage form of Frovatriptan. formulation of Frovatriptan binary ethosome into mucoadhesive nasal in situ gel to extend the drug's residence time. The particle size was 154.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!