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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864407 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078733 | PLOS |
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Extended-Release Injection vs Sublingual Buprenorphine for Opioid Use Disorder With Fentanyl Use: A Post Hoc Analysis of a Randomized Clinical Trial.
JAMA Netw Open
June 2024
Medical Affairs, Braeburn Inc, Plymouth Meeting, Pennsylvania.
Importance: Fentanyl has exacerbated the opioid use disorder (OUD) and opioid overdose epidemic. Data on the effectiveness of medications for OUD among patients using fentanyl are limited.
Objective: To assess the effectiveness of sublingual or extended-release injection formulations of buprenorphine for the treatment of OUD among patients with and without fentanyl use.
Systemic and Tumor-directed Therapy for Oligorecurrent Metastatic Prostate Cancer (SATURN): Primary Endpoint Results from a Phase 2 Clinical Trial.
Eur Urol
June 2024
Division of Hematology-Oncology University of California-Los Angeles, Los Angeles, CA, USA. Electronic address:
Article Synopsis
- Nearly all men with metastatic hormone-sensitive prostate cancer experience recurrence within 6 months after testosterone recovery when treated with intermittent androgen deprivation therapy (ADT).
- A clinical trial was conducted to see if adding dual androgen receptor pathway inhibitors (ARPIs) and targeted radiotherapy could reduce recurrence rates in men with a specific type of metastasis after prior prostate surgery.
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Impact of the Communities That HEAL Intervention on Buprenorphine-Waivered Practitioners and Buprenorphine Prescribing: A Prespecified Secondary Analysis of the HCS Randomized Clinical Trial.
JAMA Netw Open
February 2024
College of Medicine, University of Kentucky Center on Drug and Alcohol Research, Lexington.
Importance: Buprenorphine significantly reduces opioid-related overdose mortality. From 2002 to 2022, the Drug Addiction Treatment Act of 2000 (DATA 2000) required qualified practitioners to receive a waiver from the Drug Enforcement Agency to prescribe buprenorphine for treatment of opioid use disorder. During this period, waiver uptake among practitioners was modest; subsequent changes need to be examined.
View Article and Find Full Text PDFFuture of the Search for Life: Workshop Report.
Astrobiology
January 2024
Department of Chemistry, Oakland University, Rochester, Michigan, USA.
The 2-week, virtual Future of the Search for Life science and engineering workshop brought together more than 100 scientists, engineers, and technologists in March and April 2022 to provide their expert opinion on the interconnections between life-detection science and technology. Participants identified the advances in measurement and sampling technologies they believed to be necessary to perform searches for life elsewhere in our Solar System, 20 years or more in the future. Among suggested measurements for these searches, those pertaining to three potential indicators of life termed "dynamic disequilibrium," "catalysis," and "informational polymers" were identified as particularly promising avenues for further exploration.
View Article and Find Full Text PDFEffective resection of dermatofibrosarcoma protuberans using the novel Saturn's rings technique.
Medicine (Baltimore)
November 2023
Department of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Busan, Republic of Korea.
Dermatofibrosarcoma protuberans (DFSP) is a rare, low-grade sarcoma with locally infiltrative characteristics. A wide excision is made with a 5 cm gross margin. However, recently, Mohs micrographic surgery has emerged as an alternative.
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