AI Article Synopsis
- - The study examined the link between antidepressant use and gastrointestinal symptoms in the adult population, acknowledging that while antidepressants can cause GI issues, they are also used to treat GI disorders.
- - Researchers surveyed over 16,000 people, finding that 4.2% were using antidepressants; among these users, 40% reported GI symptoms compared to 25% of nonusers.
- - However, after adjusting for other factors like demographics and existing health issues, the link between antidepressant use and GI symptoms disappeared, indicating no significant association was found.
Article Abstract
Background: Gastrointestinal symptoms are frequently reported adverse effects of antidepressants, but antidepressants are also a treatment modality in functional gastrointestinal disorders. We aimed to assess the association between antidepressant use and gastrointestinal symptoms in the general adult population.
Methods: We assessed gastrointestinal symptoms, medication use, and comorbidity through structured questionnaires in randomly selected individuals. We compared presence of gastrointestinal symptoms in respondents who reported antidepressant use with those who did not. We used multivariable regression analysis to verify the association between antidepressant use and gastrointestinal symptoms.
Results: In total, 16,758 questionnaires were returned and eligible for analysis. Antidepressant use was reported by 701 respondents (4.2%). Gastrointestinal symptoms were more frequently reported by antidepressant users compared with nonusers (40% vs 25%, P < 0.01). This apparent association between antidepressant use and gastrointestinal symptoms did not remain after adjusting for demographic factors, comorbidity, and use of other medications (adjusted odds ratio, 0.94; 95% confidence interval, 0.74-1.18).
Conclusions: In our cross-sectional population-based study, we did not find an association between antidepressant use and gastrointestinal symptoms.
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| http://dx.doi.org/10.1097/JCP.0000000000000055 | DOI Listing |
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