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Exposure to environmentally relevant levels of GenX affects placental and offspring development in mice.
Environ Pollut
December 2024
College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, PR China; JointInternational Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, 400016, PR China. Electronic address:
Article Synopsis
- * A study on mice exposed to GenX showed significant changes in placental and offspring development, including altered body and placental weights and impaired placental structure from longer exposure to GenX.
- * The research revealed that subchronic exposure to GenX affected placental blood vessel formation and resulted in increased birth weights and premature puberty in offspring, suggesting potential health risks associated with GenX usage.
In silico prediction of the interaction of legacy and novel per- and poly-fluoroalkyl substances (PFAS) with selected human transporters and of their possible accumulation in the human body.
Arch Toxicol
September 2024
Department of Drug Science and Technology, University of Turin, Turin, Italy.
Per- and poly-fluorinated compounds constitute a wide group of fluorocarbon chemicals with widespread industrial applications, ranging from non-stick coating in cookware to water surfactants, from fire-fighting foams to water-repellent coatings on textiles. Presently, over 12,000 PFAS are known worldwide. In recent years, extensive research has focused on investigating the biological effects of these molecules on various organisms, including humans.
View Article and Find Full Text PDFThe role of perfluorooctane sulfonic acid (PFOS) exposure in inflammation of intestinal tissues and intestinal carcinogenesis.
Front Toxicol
August 2023
Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, United States.
PFAS (per- and polyfluoroalkyl substances) are organofluorine substances that are used commercially in products like non-stick cookware, food packaging, personal care products, fire-fighting foam, etc. These chemicals have several different subtypes made of varying numbers of carbon and fluorine atoms. PFAS substances that have longer carbon chains, such as PFOS (perfluorooctane sulfonic acid), can potentially pose a significant public health risk due to their ability to bioaccumulate and persist for long periods of time in the body and the environment.
View Article and Find Full Text PDFHealth-related toxicity of emerging per- and polyfluoroalkyl substances: Comparison to legacy PFOS and PFOA.
Environ Res
September 2022
Future Industries Institute (FII), University of South Australia, Mawson Lakes, South Australia, Australia. Electronic address:
Per- and polyfluoroalkyl substances (PFAS) are highly persistent, manufactured chemicals used in various manufacturing processes and found in numerous commercial products. With over 9000 compounds belonging to this chemical class, there is increasing concern regarding human exposure to these compounds due to their persistent, bioaccumulative, and toxic nature. Human exposure to PFAS may occur from a variety of exposure sources, including, air, food, indoor dust, soil, water, from the transfer of PFAS from non-stick wrappers to food, use of cosmetics, and other personal care products.
View Article and Find Full Text PDFPer- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression.
Nutrients
October 2021
Division of Nutritional Sciences, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.
Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals utilized in various industrial settings and include products such as flame retardants, artificial film-forming foams, cosmetics, and non-stick cookware, among others. Epidemiological studies suggest a link between increased blood PFAS levels and prostate cancer incidence, but the mechanism through which PFAS impact cancer development is unclear. To investigate the link between PFAS and prostate cancer, we evaluated the impact of metabolic alterations resulting from a high-fat diet combined with PFAS exposure on prostate tumor progression.
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