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Venous thromboembolism secondary prophylaxis in elderly people (over 75-year-old) with low-dose direct oral anticoagulants: single-center Italian experience.
Blood Coagul Fibrinolysis
October 2024
Hematology Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Nowadays, direct oral anticoagulants (DOACs) represent the gold standard for venous thromboembolism (VTE) treatment and VTE secondary prophylaxis; nevertheless, the percentage of elderly patients in major trials and literature data about DOACs usage for VTE secondary prophylaxis in the elderly are scant. Our retrospective study tried to evaluate low-dose DOACs efficacy and safety for elderly VTE secondary prophylaxis in a real-life setting. A cohort of 73 patients (≥ 75 years) considered at high risk of VTE recurrence was treated with apixaban 2.
View Article and Find Full Text PDFHemadsorption with CytoSorb®: focus on the latest experiences in cardiac surgery patients.
J Artif Organs
December 2024
Division of Cardiology, Ospedale Civile Maggiore Borgo Trento, Piazzale Stefani, Verona, (VR), Italy.
Cardiac surgery patients are potentially exposed to an acute inflammatory host response with a huge release of both pro- and anti-inflammatory cytokines both through intrinsic (e.g., tissue damage, endothelial injury) and extrinsic (e.
View Article and Find Full Text PDFIntake Patterns and Experiences of Patients Using Direct Oral Anticoagulants Measured by Electronic Monitoring in Community Pharmacies.
Patient Prefer Adherence
November 2024
Meduplace, Koninklijke Apothekersvereniging van Antwerpen, Antwerp, Belgium.
Purpose: Several international organizations advocate for monitoring of adherence to direct oral anticoagulants (DOACs), given the prevalent issue of suboptimal adherence to DOACs. The aim was to investigate intake patterns in patients on DOAC therapy by electronic monitoring of medication adherence in community pharmacies (using a Medication Event Monitoring System (MEMS)-device), and to assess patients' experiences with this device.
Patients And Methods: Patients using apixaban, rivaroxaban or edoxaban and visiting a community pharmacy, were included.
Chronic Anticoagulation in Patients Who Have Atrial Fibrillation Undergoing Outpatient Total Knee Arthroplasty: A Retrospective Matched Cohort Study.
J Arthroplasty
September 2024
Department of Orthopaedics, Brown University, Providence, Rhode Island.
Article Synopsis
- Atrial fibrillation patients often require anticoagulants like warfarin or DOACs to prevent complications, and this study investigates how these medications affect outcomes after outpatient total knee arthroplasty (TKA).
- A claims database was analyzed, comparing patients who took warfarin (4,396) or DOACs (5,383) with matched controls, both groups averaging around 70 years old.
- Results revealed that patients on warfarin had more pulmonary embolisms but fewer TKA revisions, while those on DOACs had higher pneumonia and myocardial infarction rates, but fewer surgical complications than matched controls.
Clinical and patient reported treatment outcomes of livedoid vasculopathy: A systematic review.
Clin Exp Dermatol
September 2024
Department of Dermatology, Oregon Health & Science University, Portland, OR, USA.
Article Synopsis
- * A systematic review of 44 studies with 216 patients revealed Rivaroxaban as the most commonly used treatment, leading to complete or partial healing of ulcers in the majority of cases.
- * The review emphasizes the necessity for more research to discover better treatment options and to develop standardized care protocols for LV in future clinical studies.
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