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The paradox of the self-studying brain.
Phys Life Rev
January 2025
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, UK; VERSES AI Research Lab, Los Angeles, CA, 90016, USA.
The paradox of a brain trying to study itself presents a conundrum, raising questions about self-reference, consciousness, psychiatric disorders, and the boundaries of scientific inquiry. By which means can this complex organ shift the focus of study towards itself? We aim at unpacking the intricacies of this paradox. Historically, this question has been raised by philosophers under different frameworks.
View Article and Find Full Text PDFSystemic lupus erythematosus (SLE) is a complex autoimmune disorder with multifactorial interactions among various susceptibility factors. Significant strides have been made in understanding the pathogenesis of SLE, leading to the development of targeted therapies and the exploration of alternative treatments. The approval of new therapies has expanded patient treatment options, and ongoing clinical trials promise to enhance the treatment landscape further.
View Article and Find Full Text PDFThe Nuchal Cord Conundrum: Understanding and Addressing Umbilical Entanglement in the Third Trimester of Pregnancy.
J Clin Med
November 2024
Department of Prenatal Cardiology, Polish Mother's Memorial Hospital Research Institute, 93-338 Lodz, Poland.
Better understanding of and addressing umbilical entanglement in the third trimester of pregnancy is necessary to estimate its impact on fetal circulation. An analysis of single physiological pregnancies wrapped with one or two coils of the umbilical cord around the neck makes it possible to understand the severity of the problem and distinguish it from perinatal umbilical strangulation. In an echocardiographic study performed at 32.
View Article and Find Full Text PDFPrebiotic formation of enantiomeric excess D-amino acids on natural pyrite.
Nat Commun
November 2024
School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, State Key Laboratory of Composite Materials, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University, Shanghai, China.
D-amino acids, found in excess in a minority of organisms and crucial for marine invertebrates, contrast with the more common L-amino acids in most life forms. The local prebiotic origin of D-amino acid enantiomeric excess in natural systems remains an unsolved conundrum. Herein, we demonstrate the formation of enantiomeric excess (ee) D-amino acids through photocatalytic reductive amination of α-keto acids on natural pyrite.
View Article and Find Full Text PDFComplement C1S is a potential prognostic biomarker and associated with M2 macrophage infiltration in gliomas: From bioinformatics to comprehensive experimental validation.
Int Immunopharmacol
December 2024
Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China; Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China. Electronic address:
Glioma is the most common malignant tumor of the central nervous system, and the ability of traditional clinical treatment to prolong the survival of glioma patients is limited. A substantial body of evidence underscores the pivotal role of the immune system in eradicating malignant cells and impeding tumor metastasis. Consequently, tumor immunotherapy has become a promising avenue to address the clinical conundrum faced by glioma patients.
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