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The impact of positive surgical margins after cystectomy on oncological outcomes: a nationwide study.
BJU Int
December 2024
Department of Research, The Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands.
Objective: To evaluate whether surgical margin status, alongside existing postoperative risk indicators, improves the identification of bladder cancer patients who may benefit from adjuvant therapy following radical cystectomy (RC).
Methods: In this nationwide cohort study, patients aged ≥18 years diagnosed with muscle-invasive bladder cancer (MIBC) without nodal or distant metastasis (cT2-4aN0/xM0) between November 2017 and December 2020 who underwent RC were selected from the Netherlands Cancer Registry. Detailed information on surgical margin status was obtained through linkage with the Dutch central pathology database, Palga.
Smoking behavior and the risks of tumor recurrence and progression in patients with non-muscle-invasive bladder cancer.
Int J Cancer
November 2024
IQ Health Science Department, Radboud University Medical Center, Nijmegen, The Netherlands.
Studies on the relationship of cigarette smoking with the risks of recurrence and progression of non-muscle-invasive bladder cancer (NMIBC) are inconsistent and prospective data are scarce. Therefore, we aimed to assess the association of smoking behavior with risks of NMIBC recurrence and progression. We used data of the prospective multi-center cohort study UroLife, including 1495 patients with NMIBC who reported information on smoking at 6 weeks post-diagnosis (baseline; reflecting present and pre-diagnosis).
View Article and Find Full Text PDFLifestyle Advice to Patients with Bladder Cancer: A National Survey of Dutch Urologists.
Bladder Cancer
October 2024
IQ Health Science Department, Radboud University Medical Center, Nijmegen, The Netherlands.
Background: Not much is known about the extent to which urologists discuss lifestyle with patients with bladder cancer (BC), despite patients considering urologists as an important source of information and motivation.
Objective: To determine how often lifestyle is asked about, advised on, and referred for by Dutch urologists to patients with BC, as well as to evaluate urologists' perceptions and barriers.
Methods: An anonymous online survey was sent to Dutch urologists.
Risk of Progression of High-grade Primary T1 Non-muscle-invasive Bladder cancer in a Contemporary Cohort.
Eur Urol Oncol
September 2024
Department of Urology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands. Electronic address:
Patients with high-risk non-muscle-invasive bladder cancer (NMIBC) receive bacillus Calmette-Guérin (BCG) instillations to reduce the risk of progression. For patients with very high-risk NMIBC, immediate radical cystectomy may be considered, as patients who experience disease progression despite BCG treatment have a worse prognosis. However, guideline-recommended stratification for the risk of progression is based on data from patients who were not exposed to BCG.
View Article and Find Full Text PDFThe Role of Multiparametric Magnetic Resonance Imaging and the Vesical Imaging-Reporting and Data System (VI-RADS) in the Management of Patients with Bladder Cancer: Vision of the American College of Radiology VI-RADS Steering Committee.
Eur Urol
December 2024
Department of Radiology, New York University Langone Health, New York, NY, USA.
The American College of Radiology Vesical Imaging-Reporting and Data System (VI-RADS) Steering Committee will strive to ensure high-quality imaging practices for bladder cancer (BC) and improve outcomes for BC patients. Work will involve evaluation of the current status of magnetic resonance imaging for BC and identify actionable areas to improve its utility in clinical practice. Current VI-RADS gaps related to unmet clinical needs, research areas to address, and future steps and timelines will be identified.
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