Aim: To design new derivatives of aryl-propionic acid with potential antibacterial and antioxidant activity.
Material And Methods: New hydrazone of ibuprofen (2-(4-isobutylphenyl)propionic acid) have been synthesized by reaction of ethyl ester of ibuprofen with hydrazine hydrate and then condensation of corresponding hydrazide with various aromatic aldehydes.
Results: The synthesized compounds were screened for their antibacterial activity against Gram positive (Staphylococcus aureus ATCC 25923, Sarcinalutea ATCC 9341, Bacillus cereus ATCC 14579, Bacillus subtilis) and Gram negative bacterial strains (Escherichia coli ATCC 25922). Some of them were found to have good antibacterial activity. The antioxidant activity of these compounds was also tested using the total antiox idant capacity test.
Conclusions: The chemical modulations performed on ibuprofen structure have a good influence on the biological activity of the synthesized compounds.
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