The use of a cell-based vaccine composed of autologous whole blood cells loaded with mRNA is described. Mice immunized with whole blood cells loaded with mRNA encoding antigen develop anti-tumor immunity comparable to DC-RNA immunization. This approach offers a simple and affordable alternative to RNA-based cellular therapy by circumventing complex, laborious and expensive ex vivo manipulations required for DC-based immunizations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053491 | PMC |
| http://dx.doi.org/10.1002/adhm.201300512 | DOI Listing |
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