AI Article Synopsis
- This study focuses on the genetic variations of UGT1A1, UGT2B7, and UGT2B15, key genes in drug metabolism, examining how these variations differ among five ethnic groups.
- We sequenced DNA from 288 participants from Korean, Japanese, Han Chinese, African American, and European American backgrounds to identify single nucleotide polymorphisms (SNPs) and analyze their distributions and functions.
- A total of 87 SNPs were found, with notable ethnic differences in certain core SNPs, and some novel SNPs that may affect drug response through changes in gene regulation and protein structure, highlighting the potential for personalized medicine.
Article Abstract
Purpose: UGT1A1, UGT2B7, and UGT2B15 are well-known pharmacogenes that belong to the uridine diphosphate glucuronyltransferase gene family. For personalized drug treatment, it is important to study differences in the frequency of core markers across various ethnic groups. Accordingly, we screened single nucleotide polymorphisms (SNPs) of these three genes and analyzed differences in their frequency among five ethnic groups, as well as attempted to predict the function of novel SNPs.
Materials And Methods: We directly sequenced 288 subjects consisting of 96 Korean, 48 Japanese, 48 Han Chinese, 48 African American, and 48 European American subjects. Subsequently, we analyzed genetic variability, linkage disequilibrium (LD) structures and ethnic differences for each gene. We also conducted in silico analysis to predict the function of novel SNPs.
Results: A total of 87 SNPs were detected, with seven pharmacogenetic core SNPs and 31 novel SNPs. We observed that the frequencies of UGT1A1 *6 (rs4148323), UGT1A1 *60 (rs4124874), UGT1A1 *93 (rs10929302), UGT2B7 *2 (rs7439366), a part of UGT2B7 *3 (rs12233719), and UGT2B15 *2 (rs1902023) were different between Asian and other ethnic groups. Additional in silico analysis results showed that two novel promoter SNPs of UGT1A1 -690G>A and -689A>C were found to potentially change transcription factor binding sites. Moreover, 673G>A (UGT2B7), 2552T>C, and 23269C>T (both SNPs from UGT2B15) changed amino acid properties, which could cause structural deformation.
Conclusion: Findings from the present study would be valuable for further studies on pharmacogenetic studies of personalized medicine and drug response.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874916 | PMC |
| http://dx.doi.org/10.3349/ymj.2014.55.1.232 | DOI Listing |
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