Therapeutic application of this approach to silence prolyl hydroxylase domain 2 promoted expression of pro-angiogenic genes controlled by HIF1α and enhanced scaffold vascularization . This technology provides a new standard for efficient and controllable gene silencing to modulate host response within regenerative biomaterials.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951880 | PMC |
http://dx.doi.org/10.1002/adma.201303520 | DOI Listing |
Int J Biol Macromol
January 2025
Department of Chemistry, Sri Krishnadevaraya University, Ananthapur 515003, India. Electronic address:
Composite gels are a type of soft matter, which contains a continuous three-dimensional crosslinked network and has been embedded with non-gel materials. Compared to pure gels, composite gels show high flexibility and tunability in properties and hence have attracted extensive interest in applications ranging from cancer therapy to tissue engineering. In this study, we incorporated triethylenetetramine (TETA)-functionalized cobalt ferrite nanoparticles (ANPs) into a hydrogel consisting of sodium alginate (SA) and methyl cellulose (MC), and examined the resulting composite gels for controlled drug release.
View Article and Find Full Text PDFACS Nano
January 2025
Jilin Provincial Key Laboratory of Nutrition and Functional Food, College of Food Science and Engineering, Jilin University, Changchun 130062, China.
PLoS One
December 2024
Faculty of Science, Department of Biosciences, Universiti Teknologi Malaysia, Skudai, Johor, Malaysia.
Bacterial cellulose (BC) is a novel biocompatible polymeric biomaterial with a wide range of biomedical uses, like tissue engineering (TE) scaffolds, wound dressings, and drug delivery. Although BC lacks good cell adhesion due to limited functionality, its tunable surface chemistry still holds promise. Here, hydroxyapatite (HA) was incorporated into a citrate-modified BC (MBC) using the biomimetic synthesis in simulated body fluid (SBF).
View Article and Find Full Text PDFAdv Mater
December 2024
School of Chemical Engineering, The University of Adelaide, North Terrace, South Australia, 5005, Australia.
Nanomaterials have become essential in the daily lives, finding applications in food, skincare, drugs, and vaccines. Traditionally, the surface chemistry of nanoparticles (NPs) is considered the key factor in determining their interactions with biological systems. However, recent studies have shown that the mechanical properties of nanomaterials are equally important in regulating nano-bio interactions, though they have often been overlooked.
View Article and Find Full Text PDFDevice
December 2024
Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716.
Modeling aerosol dynamics in the airways is challenging, and most modern personalized tools consider only a single inhalation maneuver through less than 10% of the total lung volume. Here, we present an modeling pipeline to produce a device that preserves patient-specific upper airways while approximating deeper airways, capable of achieving total lung volumes over 7 liters. The modular system, called TIDAL, includes tunable inhalation and exhalation breathing capabilities with resting flow rates up to 30 liters per minute.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!