Therapeutic application of this approach to silence prolyl hydroxylase domain 2 promoted expression of pro-angiogenic genes controlled by HIF1α and enhanced scaffold vascularization . This technology provides a new standard for efficient and controllable gene silencing to modulate host response within regenerative biomaterials.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951880PMC
http://dx.doi.org/10.1002/adma.201303520DOI Listing

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