Gels obtained by complexation of octablock star polyethylene oxide/polypropylene oxide copolymers (Tetronic 90R4) with α-cyclodextrin (α-CD) were evaluated as matrices for drug release. Both molecules are biocompatible so they can be potentially applied to drug delivery systems. Two different types of matrices of Tetronic 90R4 and α-CD were evaluated: gels and tablets. These gels are capable to gelifying in situ and show sustained erosion kinetics in aqueous media. Tablets were prepared by freeze-drying and comprising the gels. Using these two different matrices, the release of two model molecules, L-tryptophan (Trp), and a protein, bovine serum albumin (BSA), was evaluated. The release profiles of these molecules from gels and tablets prove that they are suitable for sustained delivery. Mathematical models were applied to the release curves from tablets to elucidate the drug delivery mechanism. Good correlations were found for the fittings of the release curves to different equations. The results point that the release of Trp from different tablets is always governed by Fickian diffusion, whereas the release of BSA is governed by a combination of diffusion and tablet erosion.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jps.23774 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Catalytically Active Gold Nanoparticles on Star Block Co-polymer Matrix: Synthesis of Nanocomposite Film Exploring the Langmuir-Blodgett Technique.
Langmuir
November 2024
Department of Chemistry, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India.
Article Synopsis
- * The synthesis highlights that T90R4 shows stronger electrostatic interaction with chloroaurate ions compared to T701, which has a more spontaneous interaction due to its hydrophobic nature.
- * Characterization methods (UV-vis, FTIR, XRD, TEM) reveal the composite's structure and optical properties, with the thin film effectively catalyzing electron transfer in organic reactions, influenced by the type of tetronic used as a stabilizer.
Effect of Hofmeister Anions Series on the Langmuir Film of Tetronic 90R4 and Tetronic 701 Block Copolymers.
Langmuir
October 2024
Department of Chemistry, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India.
The air-water interfacial behavior of Tetronic 90R4 and Tetronic 701 was studied in the presence of sodium salts with different anions namely , , , , Cl, Br, , I, and SCN. Their presence in the subphase altered the arrangement of both tetronic molecules at the air-water interface. The limiting mean molecular area of the Langmuir film for both tetronics was found to be ion specific; it increased following the series < < < < Cl< Br< < I< SCN, which was found to be aligned with the Hofmeister series of anions.
View Article and Find Full Text PDFUnraveling the Photoluminescence Properties of a Boron Nitride Nanosheet Dispersed in Different Solvents and Its Application to Generate White Light.
Langmuir
January 2024
Department of Chemistry, Indian Institute of Technology Patna, Patna 801103, Bihar, India.
Hexagonal boron nitride (h-BN) is an influential 2D nanomaterial; however, its practical optoelectronic applications rely primarily on controlling the structural defects. The photoluminescence depends explicitly on the developed vacancies and substitutional defects. The present work utilizes the concept of facile liquid-phase exfoliation of hexagonal (h) boron nitride (BN) powder in common organic solvents and cosolvent mixtures to obtain a layered boron nitride nanosheet (BNNS).
View Article and Find Full Text PDFDevelopment of highly porous calcium phosphate bone cements applying nonionic surface active agents.
RSC Adv
July 2021
Faculty of Materials Science and Ceramics, AGH University of Science and Technology Mickiewicza Av. 30 30-059 Krakow Poland
A novel way of obtaining highly porous cements is foaming them with the use of nonionic surface active agents (surfactants). In this study, foamed calcium phosphate cements (fCPCs) intended for use were fabricated by a surfactant-assisted foaming process. Three different surface active agents, Tween 20, Tween 80 and Tetronic 90R4, were used.
View Article and Find Full Text PDFInfluence of Selected Surfactants on Physicochemical Properties of Calcium Phosphate Bone Cements.
Langmuir
October 2019
Faculty of Material Science and Ceramics , AGH University of Science and Technology, Al. Mickiewicza 30 , 30-059 Krakow , Poland.
The influence of the three nonionic surface active agents such as Tween 20, Tween 80, and Tetronic 90R4 on hydrolysis, setting reaction, microstructure, and mechanical properties of alpha tricalcium phosphate (α-TCP) based materials was determined. The study revealed that the addition of any of the surfactants mentioned above slightly prolonged the setting time of the tested cements (up to 5 min). On the other hand, it was found that surfactants influence the long-term hydrolysis reaction.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!