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Ondansetron blocks fluoxetine effects in immature neurons in the adult rat piriform cortex layer II.
Neurosci Lett
December 2024
Neurobiology Unit, Institute for Biotechnology and Biomedicine (BIOTECMED), University of Valencia, Spain. Electronic address:
Neuronal structural plasticity gives the adult brain the capacity to adapt to internal or external factors by structural and molecular changes. These plastic processes seem to be mediated, among others, by the action of the neurotransmitter serotonin through specific receptors (5-HTRs). Previous studies have shown that the maturation of granule cells in the hippocampus is mediated by 5-HT3.
View Article and Find Full Text PDFEffect of serotonin receptor gene variants on substance use disorders.
Ann Med
December 2025
Department of Anatomy, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Background: Substance use disorders are multifaceted conditions influenced by both genetic and environmental factors. Serotonergic pathways are known to be involved in substance use disorder susceptibility, with genetic markers within serotonin receptor genes identified as potential risk factors.
Methods: To further explore this relationship, we conducted a study to investigate the association between several polymorphisms in five serotonin receptor genes (, , ) and substance use disorders (SUD) in Jordanian males by sequencing genotypes in 496 SUD patients and 496 healthy controls.
Retraction Note to: Sleep Deprivation-Induced Blood-Brain Barrier Breakdown and Brain Dysfunction are Exacerbated by Size-Related Exposure to Ag and Cu Nanoparticles. Neuroprotective Effects of a 5-HT3 Receptor Antagonist Ondansetron.
Mol Neurobiol
December 2024
Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, University Hospital, Uppsala University, SE-75185, Uppsala, Sweden.
Atypical antipsychotic drug olanzapine inhibits 5-HT receptor-mediated currents by allosteric and non-competitive mechanisms.
Korean J Physiol Pharmacol
December 2024
Department of Pharmacology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Olanzapine, an atypical antipsychotic, is widely used in the treatment of schizophrenia and bipolar disorder due to its modulation of dopamine and serotonin receptor systems. While its primary action involves antagonism of dopamine D2 and serotonin 5-HT (5-hydroxytryptamine)A receptors, recent evidence suggests that olanzapine also inhibits 5-HT receptors, which are ligand-gated ion channels involved in synaptic transmission in central and peripheral nervous systems. The present study aimed to investigate the action of olanzapine on 5-HT receptor-mediated currents using whole-cell voltage-clamp recordings in NCB-20 neuroblastoma cells.
View Article and Find Full Text PDFQuetiapine competitively inhibits 5-HT receptor-mediated currents in NCB20 neuroblastoma cells.
Korean J Physiol Pharmacol
December 2024
Department of Pharmacology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
The 5-hydroxytryptamine type (5-HT) receptor, a ligand-gated ion channel, plays a critical role in synaptic transmission. It has been implicated in various neuropsychiatric disorders. This study aimed to elucidate the mechanism by which quetiapine, an atypical antipsychotic, could inhibit 5-HT receptor-mediated currents in NCB20 neuroblastoma cells.
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