Amorphous alumina nanowire array efficiently delivers Ac-DEVD-CHO to inhibit apoptosis of dendritic cells.

Chem Commun (Camb)

Department of Physics and Department of Mechanical & Materials Engineering, Portland State University, P.O. Box 751, Portland, OR 97207-0751, USA.

Published: February 2014

To create an effective well-ordered delivery platform still remains a challenge. Herein we fabricate vertically aligned alumina nanowire arrays via atomic layer deposition templated by carbon nanotubes. Using these arrays, a caspase-3/7 inhibitor was delivered into DC 2.4 cells and blocked apoptosis, as confirmed by fluorescence microscopy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929101PMC
http://dx.doi.org/10.1039/c3cc48088gDOI Listing

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