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Toxicokinetic Profiling of VRP-034: Evaluating its Potential in Mitigating Polymyxin B-Associated Nephrotoxicity.
Int J Antimicrob Agents
November 2024
Venus Medicine Research Centre, India. Electronic address:
This study assessed the nephrotoxicity and toxicokinetic profile of VRP-034 (novel formulation of polymyxin B [PMB]) compared to marketed PMB over a seven-day repeat-dose regimen. Three objectives were pursued: evaluating PMB pharmacokinetics in both groups, alongside assessing VRP-034's impact on mitigating PMB-associated kidney injury; analyzing kidney injury reversibility; and validating novel kidney injury biomarkers against traditional markers using histopathology scoring. 68 Sprague-Dawley rats were divided into three groups: 30 each for marketed PMB and VRP-034 groups, and 8 for control.
View Article and Find Full Text PDFMolecular and microscopic detection of haemoprotozoan diseases in dogs from Haryana, India.
Parasitol Res
October 2024
Department of Veterinary Microbiology, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, India.
Article Synopsis
- Haemoparasitic infections are prevalent in dogs in tropical regions, with a study in Hisar, Haryana revealing a high occurrence of canine tick-borne diseases (CTBD) using both blood smears and PCR assays.
- The investigation found that 12.5% of dogs tested positive via blood smears, while PCR identified a significantly higher infection rate of 64.16%, indicating that a majority of dogs were affected by various haemoparasites.
- The study highlights the superiority of PCR testing over microscopic methods for detecting these infections and suggests incorporating molecular tests for better diagnosis and management of CTBD in canines.
Hydroxyproline increases inflammation and Uropathogenic E. coli (UPEC) infection in female rats.
Sci Rep
September 2024
Department of Urology, University of Alabama Birmingham, Birmingham, AL, USA.
Calcium oxalate (CaOx) kidney stones may be associated with urinary tract infections (UTIs). However, the mechanisms for this association are not well-established. The objective of this study was to investigate the effect of oxalate on immunity and UTI development in vivo.
View Article and Find Full Text PDFSingle-cell and bulk transcriptional profiling of mouse ovaries reveals novel genes and pathways associated with DNA damage response in oocytes.
Dev Biol
January 2025
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA. Electronic address:
Immature oocytes enclosed in primordial follicles stored in female ovaries are under constant threat of DNA damage induced by endogenous and exogenous factors. Checkpoint kinase 2 (CHEK2) is a key mediator of the DNA damage response (DDR) in all cells. Genetic studies have shown that CHEK2 and its downstream targets, p53, and TAp63, regulate primordial follicle elimination in response to DNA damage.
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