AI Article Synopsis
- In 2011, trastuzumab was approved for a quicker administration of 30 minutes if the first infusion was tolerated well.
- However, quicker infusion rates raised concerns about potential cardiovascular strain and infusion reactions.
- A study found that using a reduced volume of 100 mL saline for the infusion was well tolerated and did not increase reaction frequency, thus improving the experience for patients and healthcare providers.
Article Abstract
In 2011, trastuzumab was approved via public knowledge-based application for administration over 30 minutes from the second round if the first infusion is well tolerated. However, cardiovascular strain and the trastuzumab-specific side effect of infusion reaction induced by an increase in the infusion rate on administering trastuzumab with 250 mL saline over 30 minutes need to be considered. To address these concerns, we evaluated trastuzumab administration with a reduced volume of 100 mL saline over 30 minutes. This method was well tolerated without an increase in the frequency of infusion reaction on retrospective comparison of the 2 administration methods. Thus, administration of trastuzumab with 100 mL of saline over 30 minutes considerably reduces infusion time, benefiting both patients and healthcare providers.
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