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Changing age pattern and diverse outcomes of herpes zoster ophthalmicus: exploring the temporal trend, decrease in incident age and influence of treatment strategies.
Int Ophthalmol
November 2024
Department of Ophthalmology, All India Institute of Medical Sciences, Madhya Pradesh, Bhopal, 462020, India.
Article Synopsis
- Herpes Zoster Ophthalmicus (HZO) is increasingly affecting younger individuals, particularly those under 40 years old, which raises questions about its rising incidence in this demographic.
- A review of 56 relevant patient records showed that conjunctivitis is the most common symptom, while other eye conditions like keratitis and uveitis are also prevalent among HZO patients.
- Factors such as immune status, diet, environment, and vaccination history are contributing to the increasing trend of HZO in younger populations, highlighting the need for improved patient care and public health strategies.
Optic neuropathy as an initial manifestation of acute retinal necrosis caused by varicella zoster virus: a case report.
BMC Ophthalmol
November 2024
Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250002, China.
Article Synopsis
- * Testing revealed the presence of Varicella Zoster Virus (VZV), leading to a diagnosis of acute retinal necrosis (ARN) in both eyes.
- * After treatment with antiviral medications and steroids, the patient's vision and condition stabilized over three months, highlighting the importance of prompt diagnosis and therapy for ARN.
Truncated VZV gE Induces High-Titer Neutralizing Antibodies in Mice.
Vaccines (Basel)
October 2024
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
A contemporary public health challenge is the increase in the prevalence rates of herpes zoster (HZ) worldwide. In this work, the gE gene structure was analyzed using bioinformatics techniques, and three plasmids of varying lengths, tgE537, tgE200, and tgE350, were expressed in Chinese hamster ovary (CHO) cells. These proteins were used to immunize BALB/c mice with Al/CpG adjuvant; ELISPOT and FCM were used to evaluate cellular immunity; and ELISA, VZV microneutralization, and FAMA assays were performed to detect antibody titers.
View Article and Find Full Text PDFSegmental vitiligo distribution follows the underlying arterial blood supply territory: a hypothesis based on anatomo-clinical, pathological and physio-pathological studies.
Front Med (Lausanne)
September 2024
Vitiligo and Melasma Research Association, Bordeaux, France.
Article Synopsis
- Segmental vitiligo (SV) is a type of skin condition that usually affects one side of the body, but scientists aren't sure why it happens.
- This study looked at 140 patients to see if there's a connection between SV and the areas supplied by arteries in the skin.
- The findings suggest that the way SV shows up on the skin may relate to the blood flow from nearby arteries, which could help us better understand this skin condition.
Comparison of the efficacy of pulsed radiofrequency in treating acute herpetic neuralgia and postherpetic neuralgia in the thoracic segment.
Front Neurol
August 2024
Department of Pain Management, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'An, China.
Article Synopsis
- This study evaluated the effectiveness of pulsed radiofrequency (PRF) treatment for acute herpetic neuralgia (AHN) and postherpetic neuralgia (PHN) in patients with thoracic herpes zoster-related pain.
- Researchers analyzed data from 243 patients and measured various health scores before and after PRF treatment, finding significant improvements in the AHN group compared to the PHN group.
- The results suggest that PRF is a valuable treatment option, especially for AHN, as it leads to better pain management and improved sleep and mental health outcomes over time.
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