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While the interbreeding of Homo neanderthalensis (hereafter Neanderthal) and Anatomically modern human (AMH) has been proven, owing to the shortage of fossils and absence of appropriate DNA, the timing and geography of their interbreeding are not clearly known. In this study, we applied ecological niche modelling (maximum entropy approach) and GIS to reconstruct the palaeodistribution of Neanderthals and AMHs in Southwest Asia and Southeast Europe and identify their contact and potential interbreeding zone during marine isotope stage 5 (MIS 5), when the second wave of interbreeding occurred. We used climatic variables characterizing the environmental conditions of MIS 5 ca.
View Article and Find Full Text PDFGenomic analysis of Strongyloides stercoralis and Strongyloides fuelleborni in Bangladesh.
PLoS Negl Trop Dis
September 2024
Department of Integrative Evolutionary Biology, Max Planck Institute for Biology Tübingen, Tübingen, Germany.
Article Synopsis
- Approximately 600 million people are infected with Strongyloides stercoralis, which primarily affects humans but can also infect non-human primates, dogs, and cats, raising concerns about zoonotic transmission.
- In a study conducted in Bangladesh, researchers collected and analyzed Strongyloides and hookworm samples, discovering a higher incidence of S. fuelleborni in humans than expected, and identifying two types of S. stercoralis without evidence of genetic isolation from other regions.
- The findings suggest that S. fuelleborni may be a more significant human parasite in parts of Asia, and potential genetic exchange between S. stercoralis types could lead to important implications, such as drug resistance.
Interbreeding between farmers and hunter-gatherers along the inland and Mediterranean routes of Neolithic spread in Europe.
Nat Commun
August 2024
Complex Systems Laboratory, Universitat de Girona, C/ Maria Aurèlia Capmany 61, 17003, Girona, Catalonia, Spain.
The Neolithic (i.e., farming and stockbreeding) spread from the Near East across Europe since about 9000 years before the common era (BCE) until about 4000 yr BCE.
View Article and Find Full Text PDFChromosome Transplantation: Opportunities and Limitations.
Cells
April 2024
IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy.
There are thousands of rare genetic diseases that could be treated with classical gene therapy strategies such as the addition of the defective gene via viral or non-viral delivery or by direct gene editing. However, several genetic defects are too complex for these approaches. These "genomic mutations" include aneuploidies, intra and inter chromosomal rearrangements, large deletions, or inversion and copy number variations.
View Article and Find Full Text PDFDarwin and the White Shipwrecked Sailor: Beyond Blending Inheritance and the Jenkin Myth.
J Hist Biol
March 2024
Department of Philosophy, University Paris Nanterre, Paris, France.
This paper revisits Fleeming Jenkin's anonymous review of Charles Darwin's Origin of Species, published in the North British Review in June 1867. This review is usually revered for its impact on Darwin's theory of descent with modification. Its classical interpretation states that Jenkin, a Professor of Engineering at the University of Edinburgh, made a compelling case against natural selection based on the fact of "blending inheritance" and the "swamping" of advantageous variations.
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