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Three dimensional visualization of engineered bone and soft tissue by combined x-ray micro-diffraction and phase contrast tomography. | LitMetric

AI Article Synopsis

  • - Computed x-ray phase contrast micro-tomography is an advanced method for analyzing the 3D structure of tissue-engineered bone without damaging the samples, focusing on both bone and soft connective tissues.
  • - The study utilized a Talbot interferometer at the SYRMEP beamline in Italy to achieve detailed 3D reconstructions and combined this technique with x-ray scanning micro-diffraction to identify various tissues involved in biomineralization.
  • - Findings highlighted the differences in tissue densities, revealing the organization of amorphous calcium phosphate and collagen, which enhances our understanding of collagen’s role in the organic-mineral transition essential for creating new bio-inspired materials.

Article Abstract

Computed x-ray phase contrast micro-tomography is the most valuable tool for a three dimensional (3D) and non destructive analysis of the tissue engineered bone morphology. We used a Talbot interferometer installed at SYRMEP beamline of the ELETTRA synchrotron (Trieste, Italy) for a precise 3D reconstruction of both bone and soft connective tissue, regenerated in vivo within a porous scaffold. For the first time the x-ray tomographic reconstructions have been combined with x-ray scanning micro-diffraction measurement on the same sample, in order to give an exhaustive identification of the different tissues participating to the biomineralization process. As a result, we were able to investigate in detail the different densities in the tissues, distinguishing the 3D organization of the amorphous calcium phosphate from the collagen matrix. Our experimental approach allows for a deeper understanding of the role of collagen matrix in the organic-mineral transition, which is a crucial issue for the development of new bio-inspired composites.

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Source
http://dx.doi.org/10.1088/0031-9155/59/1/189DOI Listing

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