In recent years, some conservation biologists and conservation organizations have sought to refocus the field of conservation biology by de-emphasizing the goal of protecting nature for its own sake in favor of protecting the environment for its benefits to humans. This 'new conservation science' (NCS) has inspired debate among academics and conservationists and motivated fundamental changes in the world's largest conservation groups. Despite claims that NCS approaches are supported by biological and social science, NCS has limited support from either. Rather, the shift in motivations and goals associated with NCS appear to arise largely from a belief system holding that the needs and wants of humans should be prioritized over any intrinsic or inherent rights and values of nature.
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http://dx.doi.org/10.1016/j.tree.2013.10.013 | DOI Listing |
ChemMedChem
January 2025
Université Claude Bernard Lyon 1: Universite Claude Bernard Lyon 1, Centre de Recherche en Cancérologie de Lyon, FRANCE.
The serine/threonine protein kinase CK2, a tetramer composed of a regulatory dimer (CK2β2) bound to two catalytic subunits CK2α, is a well-established therapeutic target for various pathologies, including cancer and viral infections. Several types of CK2 inhibitors have been developed, including inhibitors that bind to the catalytic ATP-site, bivalent inhibitors that occupy both the CK2α ATP-site and the αD pocket, and inhibitors that target the CK2α/CK2β interface. Interestingly, the bivalent inhibitor AB668 shares a similar chemical structure with the interface inhibitor CCH507.
View Article and Find Full Text PDFEcol Appl
January 2025
Royal Botanic Gardens, Kew, Richmond, UK.
Determining the harvest location of timber is crucial to enforcing international regulations designed to protect natural resources and to tackle illegal logging and associated trade in forest products. Stable isotope ratio analysis (SIRA) can be used to verify claims of timber harvest location by matching levels of naturally occurring stable isotopes within wood tissue to location-specific ratios predicted from reference data ("isoscapes"). However, overly simple models for predicting isoscapes have so far limited the confidence in derived predictions of timber provenance.
View Article and Find Full Text PDFBiochemistry
January 2025
Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Enzymes of the enolase superfamily (ENS) are mechanistically diverse, yet share a common partial reaction, i.e., the metal-assisted, Bro̷nsted base-catalyzed abstraction of the α-proton from a carboxylate substrate to form an enol(ate) intermediate.
View Article and Find Full Text PDFRadiol Case Rep
March 2025
Longstreet Clinic, Breast Surgery, 725 Jesse Jewell Parkway, Gainesville, GA 30501 USA.
Adenoid cystic carcinoma (ACC) of the breast is an exceptionally rare malignancy, accounting for less than 0.1% of all breast cancers. Despite its favorable prognosis, optimal management remains undefined due to its rarity and lack of consensus guidelines.
View Article and Find Full Text PDFAJOG Glob Rep
February 2025
Tunis Medical Faculty, Tunis Centre for Maternity and Neonatal Care, Tunis El Manar University, Tunis, Tunisia (Abouda, Aloui, Azouz, Marzouk, Frikha, Hammami, Minjli, Hentati, Khila, Chanoufi, Karoui, and Hayen).
Introduction: The gold standard for treating the placenta accreta spectrum (PAS) is a cesarean hysterectomy, which harms fertility. Another conservative surgical approach allows the uterus to be preserved: one-step conservative surgery. We will compare these two approaches through the "CMNT PAS" study.
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