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Early life stress and functional connectivity in antipsychotic-naïve first episode psychosis patients.
Schizophrenia (Heidelb)
January 2025
Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Article Synopsis
- The study investigates how childhood trauma affects brain connectivity in patients experiencing their first episode of psychosis compared to healthy controls.
- Higher scores of sexual abuse and emotional neglect from childhood trauma were linked to increased functional connectivity between specific brain regions (like the amygdala and prefrontal cortex) in these patients.
- The findings suggest that different types of childhood trauma have distinct long-term effects on brain function, highlighting the complex relationship between trauma and psychosis.
The pathogenesis of depression: roles of connexin 43-based gap junctions and inflammation.
Eur J Pharmacol
January 2025
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China; Hunan University of Traditional Chinese Medicine & Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha 410208 Hunan, China. Electronic address:
Background: Depression is a leading chronic mental illness worldwide, characterized by anhedonia and pessimism. Connexin is a kind of widely distributed protein in the body. Connexin 43 (Cx43) plays an important role in the pathogenesis of depression.
View Article and Find Full Text PDFLipopolysaccharide preconditioning disrupts the behavioral and molecular response to restraint stress in male mice.
Neuroscience
January 2025
Center of Health Sciences, Department of Physiology and Pharmacology, Federal University of Santa Maria, Santa Maria, RS, Brazil; Center of Health Sciences, Postgraduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address:
Major depressive disorder (MDD) is a complex neuropsychiatric disorder potentially influenced by factors such as stress and inflammation. Chronic stress can lead to maladaptive brain changes that may trigger immune hyperactivation, contributing to MDD's pathogenesis. While the involvement of inflammation in MDD is well established, the effects of inflammatory preconditioning in animals subsequently exposed to chronic stress remain unclear.
View Article and Find Full Text PDFFunctional connectome gradient of prefrontal cortex as biomarkers of high risk for internet gaming disorder.
Neuroimage
January 2025
School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, Peoples R China; Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia 014010, Peoples R China; Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, Shaanxi, 710071, Peoples R China; Xi'an Key Laboratory of Intelligent Sensing and Regulation of trans-Scale Life Information, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710126, Peoples R China. Electronic address:
Adolescents and young adults are considered a high-risk group for internet gaming disorder (IGD). Early screening for high-risk individuals with IGD and exploring the underlying neural mechanisms is an effective strategy to reduce the harm of IGD. We recruited 219 non-internet gaming addicted college students and evaluated them with magnetic resonance imaging, followed by a two-year longitudinal follow-up.
View Article and Find Full Text PDFThe association among individual gray matter volume of frontal-limbic circuitry, fatigue susceptibility, and comorbid neuropsychiatric symptoms following COVID-19.
Neuroimage
January 2025
Department of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China. Electronic address:
Article Synopsis
- The study investigates the neurobiological factors that make individuals susceptible to fatigue after a mild COVID-19 infection, aiming to understand the link between brain structure and post-COVID neuropsychiatric symptoms.
- Researchers used neuropsychiatric assessments and MRI scans on individuals who had COVID-19 and a control group to analyze brain regions related to fatigue.
- Results indicate that specific brain areas, particularly the right dorsolateral prefrontal cortex, are linked to fatigue severity and can predict ongoing fatigue symptoms months after the infection, shedding light on the neural underpinnings of post-COVID conditions.
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