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Fatal ascending paralysis after typhoid vaccine: Guillain and Barré's description of the very first case.
Vaccine
December 2024
Professor of Neurology and the History of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905., United States. Electronic address:
Article Synopsis
- - The study revisits the historical context of Guillain-Barré syndrome (GBS) linked to vaccines, focusing on the first case documented during WWI related to a typhoid vaccine.
- - A detailed review of a case involving a 31-year-old brigadier revealed that after receiving a typhoid vaccine, he quickly experienced severe muscle weakness leading to respiratory failure, with specific findings in his cerebrospinal fluid.
- - The case marks the earliest instance of vaccine-associated GBS, highlighting the association, albeit rare, between vaccines and this neurological condition.
Osmotic demyelination syndrome: revisiting the diagnostic criteria through two fatal cases.
BMC Neurol
November 2024
Department of Anatomical, Histological, Forensic and Orthopedic Sciences, "Sapienza" University of Rome, Rome, 00185, Italy.
Background: Osmotic Demyelination Syndrome (ODS) encompasses Central Pontine Myelinolysis and Extrapontine Myelinolysis, both of which are serious neurological conditions linked to the overly rapid correction of hyponatremia. Despite growing evidence, the exact etiology of ODS remains incompletely understood. The present paper describes two case studies, aiming to provide a comprehensive overview of the pathological findings and clinical outcomes associated with ODS.
View Article and Find Full Text PDFThe Role of Nucleocapsid Protein (NP) in the Immunology of Crimean-Congo Hemorrhagic Fever Virus (CCHFV).
Viruses
September 2024
Department of Medical Microbiology, School of Medicine and Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakıf University, Istanbul 34093, Türkiye.
Crimean-Congo hemorrhagic fever virus (CCHFV) is an from the order that is widely distributed geographically and causes severe or fatal infections in humans. The viral genome consists of three segmented negative-sense RNA molecules. The CCHFV nucleocapsid protein (CCHFV NP) is encoded by the smallest segment of the virus.
View Article and Find Full Text PDFSafety of hepatitis E vaccine in pregnancy: an emulated target trial following a mass reactive vaccination campaign in Bentiu internally displaced persons camp, South Sudan.
Lancet Glob Health
November 2024
Epicentre, Paris, France.
Background: Epidemic forms of hepatitis E cause high mortality among pregnant people, with case fatality risks over 30% and adverse fetal outcomes. In 2022, the first mass reactive vaccination campaign against hepatitis E was conducted in South Sudan with the HEV239 vaccine. We aimed to assess whether vaccination against hepatitis E in pregnancy increases the risk of fetal loss in a cohort of vaccinated and unvaccinated pregnant people.
View Article and Find Full Text PDFRevisiting the Occupational Health Impact of Right-to-Work Laws: A Research Note.
Demography
October 2024
Department of Educational Administration and Policy, The Chinese University of Hong Kong, Hong Kong, China.
This research note reevaluates the occupational health impact of right-to-work (RTW) legislation, incorporating recent developments in causal inference techniques. In an era marked by an uptick in the adoption of anti-union legislation and increases in workplace fatalities and injuries, it is particularly urgent to examine the extent to which RTW laws affect workers' health. Using a state-year-level dataset spanning 28 years and collected from multiple data sources, we apply an innovative generalized synthetic control method to overcome several limitations of the traditional two-way fixed-effects approach to examine the effect of RTW laws on occupational fatal injuries as well as various other health outcomes.
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