Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/1744-9987.12122 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Outcomes in patients with thrombotic microangiopathy associated with a trigger following plasma exchange: A systematic literature review.
Transfus Apher Sci
December 2024
Alexion, AstraZeneca Rare Disease, 121 Seaport Blvd, Boston, MA 02210, USA. Electronic address:
Plasma exchange (PE) outcomes in patients with trigger-associated thrombotic microangiopathy (TMA) have not been comprehensively reviewed. Embase and MEDLINE® were searched on 03/14/2022 for English language articles published after 2007, alongside a congress materials search (2019-2022; PROSPERO: CRD42022325170). Studies with patients with trigger-associated TMA (excluding thrombotic thrombocytopenic purpura, 'typical' hemolytic uremic syndrome caused by Shiga toxin-producing Escherichia coli, post-partum TMA, and TMAs with known genetic cause) who received PE or plasma infusion (PI) and reported treatment response (including measures), safety, patient-/caregiver-reported outcomes, or economic burden data were examined.
View Article and Find Full Text PDFComparative efficacy of liberal and restrictive blood transfusion strategies in anemic patients with acute myocardial infarction: A systematic review and meta-analysis of randomized controlled trials.
Transfusion
December 2024
School of Pharmacy, IMU University, Kuala Lumpur, Malaysia.
Introduction: Acute myocardial infarction (AMI) poses a significant global health burden, warranting meticulous management strategies, particularly in patients with concurrent anemia. Blood transfusion strategies play a pivotal role in optimizing oxygen delivery while minimizing transfusion-related risks. Two contrasting approaches, liberal and restrictive transfusion strategies, have emerged, yet their comparative effectiveness remains uncertain due to conflicting evidence.
View Article and Find Full Text PDFInterleukin 6 Inhibition May Be Effective in Mitigating the Severity of Transfusion-Related Acute Lung Injury.
R I Med J (2013)
January 2025
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
The Safety Profile of COVID-19 Convalescent Plasma.
Curr Top Microbiol Immunol
December 2024
Department of Health and Kinesiology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Despite concerns about potential side effects, based both on historical experience with plasma products and more recent concerns about contemporary use of plasma, COVID-19 convalescent plasma has been shown to be a very safe product. Research early in the COVID-19 pandemic documented-among the very large population of convalescent plasma recipients in the US Convalescent Plasma Study component of the FDA-authorized Expanded Access Program-that the overall risk profile was no different than that seen for fresh frozen plasma, a product used routinely in medical practice. The safety of CCP was further demonstrated using real-world evidence, pragmatic trials, and formal randomized trials.
View Article and Find Full Text PDFKey features of the underlying pathophysiology of Transfusion-related acute lung injury.
Expert Rev Hematol
December 2024
Sanquin Research, Department of Experimental Immunohematology, Amsterdam and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Article Synopsis
- Transfusion-related acute lung injury (TRALI) is a serious and often overlooked complication of blood transfusions, particularly in intensive care settings, contributing significantly to transfusion-related mortality.
- The review highlights important aspects of TRALI's pathophysiology, emphasizing the role of complement activation and the involvement of immune cells like neutrophils and macrophages, as well as the pulmonary endothelium.
- It calls for better reporting of TRALI cases and further research to identify biomarkers and potential therapies, suggesting that interleukin-10, complement inhibition, and Osteopontin blockade could be promising strategies, with a need for future clinical trials.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!