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Clinical Characteristics, Identification, and Treatment of Lichen Planus: A Case Report.
Cureus
July 2024
Orthodontics and Dentofacial Orthopaedics, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Women are primarily affected by lichen planus, a chronic autoimmune skin and mucosal disorder in their 40s to 60s. Medication, systemic disorders, and mental stress are some of the factors that can cause it, though the precise cause is still unknown. Middle-aged females are the main victims of the disease; children are rarely affected.
View Article and Find Full Text PDFCase report: Lichenoid eruption under immunotherapy with MK-4830 and pembrolizumab in a breast cancer patient.
Front Pharmacol
August 2024
Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
Background: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, yet they can induce immune-related adverse events (irAEs), including cutaneous toxicities such as lichenoid eruptions. Pembrolizumab, a PD-1 inhibitor, is known for its association with lichen-planus-like reactions, while the side effect profile of combining immunotherapy with MK-4830, a novel fully human IgG4 monoclonal antibody that targets ILT-4, remains limited.
Case Report: We present a case of a 47-year-old female with metastatic breast cancer who developed a grade 2 Common Terminology Criteria for Adverse Events (CTCAE) lichenoid reaction after 9 months of MK-4830 and pembrolizumab use.
Actinic Lichen Planus: Significance of Dermoscopic Assessment.
Cureus
March 2023
Dermatology, Venereology and Leprosy, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Article Synopsis
- - Actinic lichen planus (LP) is a rare variant of lichen planus, a chronic inflammatory skin condition affecting 1-2% of the population, typically presenting as pruritic, purplish, polygonal papules.
- - In actinic LP, lesions appear in sun-exposed areas like the face and hands, with the absence of Koebner's phenomenon, and may be confused with conditions such as discoid lupus erythematosus and granuloma annulare.
- - Dermoscopy is a valuable, non-invasive tool for diagnosis, revealing features like "Wickham's striae," and treatment generally involves corticosteroids; a case study describes a 50-year-old woman whose
Porokeratotic Variant of Lichen Planus.
Skinmed
November 2022
Department of Pathology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
A 44-year-old woman presented with mildly itchy, brownish-black plaques for the last 2 years. The lesions first appeared on the upper back, followed by involvement of the face and upper arms within 4-5 months. Individual lesions began as small papules that gradually evolved into small, annular, and barely palpable plaques.
View Article and Find Full Text PDFGold Dental Implant-Induced Oral Lichen Planus.
Cureus
February 2022
Medical Education, University of Miami Miller School of Medicine, Miami, USA.
Lichen planus is a chronic inflammatory cutaneous and mucosal disease mostly affecting middle-aged individuals. The etiology of lichen planus is unknown, but current literature suggests that it is an altered immune response characterized by dysregulated T-cell activation and subsequent inflammation which can be associated with conditions like allergic contact dermatitis and hepatitis C. Additionally, heavy metals like lead, tin, arsenic, and bismuth can create inflammatory and allergic reactions that can predispose to the formation of lichen planus.
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