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Simultaneous Treatment of Two Severe Acute Intoxication and Acute Kidney Injury.
Semin Dial
December 2024
Nephrology, Dialysis and Kidney Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Extracorporeal therapies could be required for treatment of life-threatening severe acute intoxication. We present the case of an 82-year-old patient admitted to our Nephrology Unit because of metformin-associated lactic acidosis (MALA) and acute kidney injury (AKI stage III AKIN criteria). The patient also presented severe intoxication of digoxin and apixaban.
View Article and Find Full Text PDF[Acute blindness in a patient with metformin-associated lactic acidosis].
Ned Tijdschr Geneeskd
October 2024
Zaans Medisch Centrum, afd. Interne Geneeskunde, Zaandam.
Lactic acidosis is a rare metabolic complication that can occur in patients with diabetes mellitus type 2 who use metformin. We discuss a 79-year old woman with metformin-associated lactic acidosis (MALA) and acute kidney injury based on gastroenteritis. Patient reported acute blindness which in literature is described as a rare presentation of a metabolic acidosis (regardless of its underlying cause).
View Article and Find Full Text PDFTrends in Antidiabetic Drug Use and Safety of Metformin in Diabetic Patients with Varying Degrees of Chronic Kidney Disease from 2010 to 2021 in Korea: Retrospective Cohort Study Using the Common Data Model.
Pharmaceuticals (Basel)
October 2024
Department of Regulatory Science, College of Pharmacy, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Article Synopsis
- The study aimed to analyze trends in the use of antidiabetic medications in patients with chronic kidney disease (CKD) and identify the risk of metformin-associated lactic acidosis (MALA).
- It involved a review of electronic medical records from 2010 to 2021, focusing on patients over 18 with both CKD and type 2 diabetes who had been on antidiabetic drugs for at least 30 days.
- Metformin was the most commonly prescribed drug for earlier stages of CKD, but its use declined significantly in advanced stages, while SGLT2 and DPP-4 inhibitors saw increased prescriptions, highlighting varying treatment patterns and low MALA risk in CKD patients.
Urgent-Start Peritoneal Dialysis in Metformin-Associated Lactic Acidosis: A Critical Alternative when Immediate Hemodialysis Is Unavailable.
Blood Purif
October 2024
Kidney Service Plan R 9 Commitee, The Ministry of Public Health, Nonthaburi, Thailand.
Introduction: Intermittent hemodialysis (IHD) is a preferable renal replacement therapy (RRT) option in metformin-associated lactic acidosis (MALA) due to rapid correct metabolic acidosis. However, IHD might not be started immediately. Immediate urgent-start peritoneal dialysis (iUSPD) is used as a life-saving dialysis option and then followed by IHD.
View Article and Find Full Text PDFMetformin-associated lactic acidosis: a serious complication of a common drug.
BMJ Case Rep
September 2024
Division of Hospital Medicine, Miriam Hospital, Providence, Rhode Island, USA.
Article Synopsis
- Metformin-associated lactic acidosis (MALA) is a rare but serious complication primarily affecting diabetic patients with additional risk factors like kidney issues or certain medications.
- The case study discusses a man in his 70s who developed MALA after experiencing severe gastrointestinal symptoms alongside acute kidney injury, likely due to inadequate food intake and antibiotic use.
- Treatment involved intravenous fluids and bicarbonate, which quickly improved his symptoms and restored kidney function within 12 days, emphasizing the need for awareness of MALA among diabetic patients.
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