Rhinosinusitis is one of the most common conditions seen by family physicians. Most cases are viral in nature and resolve spontaneously. When symptoms persist for 10 days or more or are accompanied by severe pain and fever, bacterial sinusitis may be present. Current guidelines recommend that acute bacterial sinusitis be treated with amoxicillin-clavulanate. Chronic bacterial sinusitis typically involves a change in the sinus ostia and microbiology. This rarely resolves with antibiotic treatment alone and often warrants surgical intervention. Fungal sinusitis is a rare condition seen more often in immunosuppressed individuals and manifests in severe symptoms along with possible neurologic findings.
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Pediatr Infect Dis J
October 2024
From the Section of Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
Background: When coronavirus disease 2019 (COVID-19) mitigation efforts waned, viral respiratory infections (VRIs) surged, potentially increasing the risk of postviral invasive bacterial infections (IBIs). We sought to evaluate the change in epidemiology and relationships between specific VRIs and IBIs [complicated pneumonia, complicated sinusitis and invasive group A streptococcus (iGAS)] over time using the National COVID Cohort Collaborative (N3C) dataset.
Methods: We performed a secondary analysis of all prospectively collected pediatric (<19 years old) and adult encounters at 58 N3C institutions, stratified by era: pre-pandemic (January 1, 2018, to February 28, 2020) versus pandemic (March 1, 2020, to June 1, 2023).
J Pediatric Infect Dis Soc
December 2024
University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, CSC Room H4 554, Madison, WI.
medRxiv
December 2024
School of Public Health, University of California, Berkeley, Berkeley, California, United States.
Background: (pneumococcus) causes invasive pneumococcal disease (IPD) and non-invasive acute respiratory infections (ARIs). Three pneumococcal conjugate vaccines (PCVs) are recommended in the United States with additional products in clinical trials. We aimed to estimate 1) proportions of IPD cases and pneumococcal ARIs caused by serotypes targeted by existing and pipeline PCVs and 2) annual U.
View Article and Find Full Text PDFBMC Prim Care
December 2024
Department of Endocrinology, University hospital Dubrava, Zagreb, Croatia, and School of Medicine, and University of Zagreb, Zagreb, Croatia.
Background: Acute respiratory tract infections are common in primary healthcare care settings and frequently result in antibiotic prescriptions, despite being primarily viral. There is scarcity of research examining impact of academic detailing (AD) intervention on prescribing practices for these infections in resource-constrained healthcare settings like southeastern Europe. Therefore aim of this study was to evaluate impact of AD intervention as an antimicrobial stewardship measure on antibiotic prescribing for acute respiratory tract infections in primary setting in Croatia which is located in southeastern Europe.
View Article and Find Full Text PDFmBio
December 2024
Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
Unlabelled: is an important human pathogen that normally resides in the human nasopharynx. Competence-mediated bacteriocin expression by plays a major role in both the establishment and persistence of colonization on this polymicrobial surface. Over 20 distinct bacteriocin loci have been identified in pneumococcal genomes, but only a small number have been characterized phenotypically.
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