AI Article Synopsis
- The study investigates the impact of the IL-6-174G/C genetic variant on the risk of developing multiple sclerosis (MS).
- The meta-analysis included six studies and found no overall significant association between the polymorphism and MS, but highlighted that Asian carriers of the IL-6-174CC genotype had a higher risk (1.87 times) for developing MS.
- The findings suggest that this genetic variant may be a potential risk factor for MS in Asian populations, but more research is needed to verify these results across different ethnic groups.
Article Abstract
Objective: Interleukin-6 (IL-6) is a pleiotropic cytokine and important mediator of many inflammatory processes, which might affect susceptibility to multiple sclerosis (MS). The aim of this study was to assess the effect of IL-6-174G/C polymorphism on the risk of MS using a meta-analysis.
Materials And Methods: The Pubmed, ISI Web of Science, Wanfang, VIP, and China National Knowledge Infrastructure databases were screened and six studies were included in the meta-analysis. Pooled odds ratios (ORs) with corresponding 95% confidence intervals (CI) were calculated to evaluate the association between the IL-6-174G/C polymorphism and risk of MS.
Results: No significant association between the IL-6-174G/C polymorphism and risk of MS was observed in overall analyses. With stratification according to ethnicity, we found that carriers with the IL-6-174CC genotype had a 1.87-fold increased risk for the development of MS in Asians (recessive model: OR=1.87, 95% CI, 1.08-3.24), but not in Caucasians.
Conclusion: This meta-analysis provides evidence that the IL-6-174G/C polymorphism may be a risk factor for the development of MS in Asians. Further association studies with a larger sample size are required to confirm the result in different populations.
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| http://dx.doi.org/10.1089/gtmb.2013.0387 | DOI Listing |
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