Copper-catalyzed intermolecular cyanotrifluoromethylation of alkenes.

Org Lett

State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P.R. China.

Published: January 2014

A novel and highly practical reaction for the copper-catalyzed intermolecular cyanotrifluoromethylation of alkenes is presented here. This methodology provides a general and straightforward way to synthesize a variety of useful CF3-containing nitriles, which can be used for further preparation of pharmaceutically and agrochemically important compounds in synthetic organic chemistry.

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http://dx.doi.org/10.1021/ol403263cDOI Listing

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