We are describing a case of 55-year-old obese female with significant history of uncontrolled rheumatoid arthritis, who recently had decreased her immune-suppression medications. She presented with extensive acral gangrene involving multiple fingers and toes. Clinical picture and laboratory findings were suggestive of vasculitis; however, skin biopsy established diagnosis of calciphylaxis, in settings of normal kidney function. Patient was treated with sodium thiosulfate with gradual improvement in her skin lesions.
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http://dx.doi.org/10.4103/2231-0770.120504 | DOI Listing |
Pain Pract
September 2024
Anesthesiology and Pain Medicine, Rijnstate Ziekenhuis, Elst, The Netherlands.
Cureus
April 2024
College of Medicine, King Faisal University, Al-Hofuf, SAU.
Symmetrical peripheral gangrene (SPG) is a rare yet severe condition characterized by peripheral ischemic lesions without significant vascular occlusion. Its clinical presentation includes peripheral cyanosis, mottling, and symmetrical ischemia of distal limbs, often progressing to gangrene. Recent years have seen a rise in SPG cases, with mortality rates ranging from 40% to 90%.
View Article and Find Full Text PDFJ Assoc Physicians India
January 2024
Consultant Hematopathologist, GKNM Hospital, Coimbatore, Tamil Nadu, India.
Background: Peripheral T cell lymphoma (PTCL), not otherwise specified (NOS) is a heterogenous group of predominantly nodal T cell lymphomas that generally presents with lymphadenopathy with or without extra nodal involvement. Acral vascular syndrome clinically presents as digital ischemia with Raynaud's phenomenon and acral cyanosis. Although, this condition is commonly associated with connective tissue disorder, smoking and vasculitis, its association with lymphoid malignancy is very rare.
View Article and Find Full Text PDFSemin Thromb Hemost
July 2024
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Ischemic limb injury can be broadly classified into arterial (absent pulses) and venous/microvascular (detectable pulses); the latter can be divided into two overlapping disorders-venous limb gangrene (VLG) and symmetrical peripheral gangrene (SPG). Both VLG and SPG feature predominant acral (distal) extremity ischemic necrosis, although in some instances, concomitant nonacral ischemia/skin necrosis occurs. Historically, for coagulopathic disorders with prominent nonacral ischemic necrosis, clinician-scientists implicated depletion of natural anticoagulants, especially involving the protein C (PC) system.
View Article and Find Full Text PDFAnn Med Surg (Lond)
February 2024
Student Research Committee, School of Medicine.
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