AI Article Synopsis
- The study assessed HLA-DPA1 and DPB1 matching in unrelated donor-recipient pairs already matched for other HLA loci (A, B, C, DRB1, DQB1).
- Out of 76 pairs, the matching rates for HLA-DPA1 and DPB1 were notably low, with 73.7% having at least one incompatible DPA1 allele and 57.9% having at least one incompatible DPB1 allele.
- The findings suggest that the overall compatibility between donors and recipients in these genes is limited, highlighting the need for further research into the clinical implications of HLA-DPA1 and DPB1 matching in stem cell transplants.
Article Abstract
Objective: To analyze the status of HLA-DPA1 and DPB1 matching for unrelated donor-recipient pairs matched at high-resolution allele level for HLA-A, B, C, DRB1 and DQB1 loci.
Methods: A total of 76 unrelated donor-recipient pairs matching at allele level for HLA-A, B, C, DRB1 and DQB1 loci were subjected to HLA-DPA1 and DPB1 sequence-based typing (SBT). HLA-DPA1and DPB1 matching status at high-resolution allelic level was also analyzed.
Results: The allelic identity ratio for single HLA-DPA1 and DPB1 were 17.1% and 9.2%, respectively. HLA-DPA1 and DPB1 allelic identity ratio were both very low. The majority of unrelated donor-recipient pairs (73.7%) had an incompatibility at 1 HLA-DPA1 allele, 9.2% of pairs had an incompatibility at 2 DPA1 alleles. As for the high-polymorphic HLA-DPB1 gene, 57.9% of studied donor-recipient pairs had an incompatibility at 1 HLA-DPB1 allele, almost 1/3 (32.9%) of them were completely incompatible. When HLA-DPA1 and DPB1 genes were analyzed together, the donor-recipient pairs matched at 2/4 was the most common (51.4%), 4/4 allelic complete matched pairs accounted for 5.6%, and 0/4 matched pairs accounted for 8.3%.
Conclusion: Our results indicated that the ratio of HLA-DPA1 and DPB1 complete match in the unrelated donor-recipient pairs matching at allelic level for HLA-A, B, C, DRB1 and DQB1 loci were very low. The effect of HLA-DPA1 and DPB1 matching status on clinical unrelated stem cell transplantation still needs to be elucidated.
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| http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2013.06.014 | DOI Listing |
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