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| http://dx.doi.org/10.1038/bjc.2013.776 | DOI Listing |
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Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study.
Cardiovasc Diabetol
January 2025
Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Background: Type 2 diabetes (T2D) has been linked to changes in DNA methylation levels, which can, in turn, alter transcriptional activity. However, most studies for epigenome-wide associations between T2D and DNA methylation comes from cross-sectional design. Few large-scale investigations have explored these associations longitudinally over multiple time-points.
View Article and Find Full Text PDFAbnormal methylation of Mill1 gene regulates osteogenic differentiation involved in various phenotypes of skeletal fluorosis in rats and methionine intervention.
Ecotoxicol Environ Saf
December 2024
School of Public Health, Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 561113, China. Electronic address:
Excessive fluoride intake can lead to skeletal fluorosis. Nutritional differences in the same fluoride-exposed environment result in osteosclerosis, osteoporosis, and osteomalacia. DNA methylation has been found to be involved in skeletal fluorosis and is influenced by environment and nutrition.
View Article and Find Full Text PDFEpigenetic regulation of HOXA3 and its impact on oral squamous cell carcinoma progression.
Oral Surg Oral Med Oral Pathol Oral Radiol
November 2024
Department of Oral Pathology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India; Academic Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, ST10 2TN, UK; Academic Unit of Oral Biology and Oral Pathology, Oman Dental College, P.O Box 835, Mina Al Fahal, Muscat, Wattayah 116, Oman. Electronic address:
Objective: The role of homeobox A3 (HOXA3) in cancer progression is gaining prominence, however, to date, no studies have investigated its regulatory function in oral cancer. In this study, we explored the role of HOXA3 through epigenetic mechanisms.
Methods: Clinical samples were collected from 25 potentially malignant oral lesions and 50 oral squamous cell carcinoma (OSCC) patients, categorized into low-stage and high-stage tumors.
The amniote-conserved DNA-binding domain of CGGBP1 restricts cytosine methylation of transcription factor binding sites in proximal promoters to regulate gene expression.
BMC Genom Data
November 2024
Department of Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar, Gandhinagar, India.
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BDNF methylation associated with stress in women: Novel insights in epigenetics and inflammation.
Brain Behav Immun Health
December 2024
Department of Pathology, Graduate Program in Pathology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
The brain-derived neurotrophic factor (BDNF) gene plays an important role in modulating the stress-response axis and inflammation, which can be regulated by epigenetic mechanisms. BNDF methylation has been associated with stress-related psychiatric disorders such as depression, anxiety and post-traumatic stress. Previous studies have reported that stressful events are involved with long-lasting alterations in DNA methylation (DNAm) of the BNDF exon IV promoter, suggesting that glucocorticoids and inflammatory cytokines can regulate this process.
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