AI Article Synopsis
- Oligonol is a functional food derived from green tea catechins and proanthocyanidins, produced through a unique manufacturing process.
- A 13-week study on rats tested various doses (100, 300, and 1000 mg/kg/d) to see if Oligonol caused nasal toxicity, with clinical signs and mortality remaining unaffected.
- The study found no nasal lesions or significant health changes, reinforcing Oligonol's safety for human use.
Article Abstract
Oligonol is a functional food containing catechin-type monomers and proanthocyanidin oligomer converted from polymer forms via a novel manufacturing process. The catechin component of green tea extract has been associated with nasal toxicity in rats following subchronic exposure. To assess the potential for Oligonol to induce nasal toxicity a 13-week repeated oral dose toxicity study was conducted in rats using doses of 100, 300, and 1000 mg/kg/d. Clinical signs and mortality were not affected by Oligonol treatment. Compound-colored stools and an increase in food consumption were observed in some treated groups; however, there were no treatment-related differences in terminal body weights or with respect to the results of the gross postmortem examinations. Histopathological evaluation of the nasal cavity tissues revealed no treatment-related lesions. The results from this toxicity study indicate that Oligonol does not induce nasal toxicity and further supports the results of previous studies demonstrating the safety of Oligonol for human consumption.
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| http://dx.doi.org/10.1016/j.yrtph.2013.12.001 | DOI Listing |
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