AI Article Synopsis
- The study investigates the link between the MSX1 671 T>C gene variant and Non Syndromic tooth agenesis in patients from Raichur, highlighting the potential genetic basis of this condition.
- Blood samples were collected from 50 patients with Non Syndromic tooth agenesis and 50 controls for genomic analysis through PCR and RFLP techniques.
- The findings indicate a significant correlation between the MSX1 gene variant and tooth agenesis, suggesting it may serve as a useful screening marker for the condition.
Article Abstract
Background: Non Syndromic tooth agenesis is a congenital anomaly with significant medical, psychological and social ramifications. There is sufficient evidence to hypothesize that locus for this condition can be identified by candidate genes. The aim of this study was to test whether MSX1 671 T>C gene variant was involved in etiology of Non Syndromic tooth agenesis in Raichur Patients.
Materials & Methods: Blood samples were collected with informed consent from 50 subjects having Non Syndromic tooth agenesis and 50 controls. Genomic DNA was extracted from the blood samples, Polymerase Chain Reaction was performed (PCR) and Restriction Fragment Length Polymorphism (RFLP) was performed for digestion products that were evaluated.
Results: The RESULTS showed positive correlation between MSX1671 T>C gene variant and Non Syndromic tooth agenesis in Raichur Patients.
Conclusion: MSX1 671 T>C gene variant may be a good screening marker for Non Syndromic tooth agenesis in Raichur Patients . How to cite this article:Reddy NA, Adusumilli G, Devanna R, Pichai S, Rohra MG, Arjunan S. Msx1 Gene Variant - Its Presence in Tooth Absence - A Case Control Genetic Study. J Int Oral Health 2013; 5(5):20-6.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845280 | PMC |
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