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Metabolic Differences in Neuroimaging with [F]FDG in Rats Under Isoflurane and Hypnorm-Dormicum.
Tomography
January 2025
Department of Nuclear Medicine & PET, Aarhus University Hospital, 8200 Aarhus, Denmark.
Background: Anesthesia can significantly impact positron emission tomography (PET) neuroimaging in preclinical studies. Therefore, understanding these effects is crucial for accurate interpretation of the results. In this experiment, we investigate the effect of [F]-labeled glucose analog fluorodeoxyglucose ([F]FDG) uptake in the brains of rats anesthetized with two commonly used anesthetics for rodents: isoflurane, an inhalation anesthetic, and Hypnorm-Dormicum, a combination injection anesthetic.
View Article and Find Full Text PDFImaging Demyelinated Axons After Spinal Cord Injuries with PET Tracer [F]3F4AP.
J Nucl Med
January 2025
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;
Spinal cord injuries (SCIs) often lead to lifelong disability. Among the various types of injuries, incomplete and discomplete injuries, where some axons remain intact, offer potential for recovery. However, demyelination of these spared axons can worsen disability.
View Article and Find Full Text PDFImpact of driving characteristic parameters and vehicle type on fuel consumption and emissions performance over real driving cycles.
PLoS One
January 2025
Department of Agricultural Engineering, Technical and Vocational University, Tehran, Iran.
With the growing need for sustainable transportation solutions, understanding the relationship between driving characteristic parameters, vehicle type, and their impact on emissions and fuel consumption over real driving scenarios is becoming increasingly important. In this paper, four conventional vehicles and one hybrid vehicle with different technologies were compared in four distinct routes in Tehran city. Nineteen real driving cycles were generated using widely employed K-means and PCA algorithms.
View Article and Find Full Text PDFHIV Infection Complicated with Cytomegalovirus Colitis: A Case Report of 18FFDG PET/CT Imaging.
Curr Med Imaging
January 2025
Department of Nuclear Medicine, Hangzhou Cancer Hospital, Hangzhou 310002, China.
Background: Cytomegalovirus (CMV) infection is common in the digestive and central nervous systems and can infect the entire digestive tract from the mouth to the rectum. In immunocompromised patients, CMV infection is prone to develop into CMV disease, especially in Acquired Immune Deficiency Syndrome (AIDS) patients. Severe cases may accelerate the progression of AIDS patients and form systemic CMV infection.
View Article and Find Full Text PDFCigarette smoking is associated with reduced neuroinflammation and better cognitive control in people living with HIV.
Neuropsychopharmacology
January 2025
Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
People living with HIV (HIV+) are roughly twice as likely to smoke cigarettes (Smok+) as the general population. With the advent of effective antiretroviral therapies, it is increasingly important to understand the effects of chronic HIV infection and cigarette smoking on brain function and cognition since HIV+ individuals have heightened neuroinflammation and cognitive deficits even with such therapies. Based on prior studies demonstrating that smoking reduces a marker for neuroinflammation in HIV- individuals, we hypothesized that HIV+/Smok+ individuals would have less neuroinflammation and better cognitive control than HIV+/Smok- individuals.
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