AI Article Synopsis
- A series of new fused triazolo- and tetrazolopyrimidine derivatives were created and tested for their anti-inflammatory and ulcerogenic properties.
- Several of these compounds exhibited significant anti-inflammatory effects, similar to a standard reference drug.
- The toxicity levels of the compounds were assessed by determining their LD50 values, and their structures were confirmed using various analytical techniques like IR and 1H-NMR.
Article Abstract
A new series of fused triazolo- and tetrazolopyrimidine derivatives 2-14 were synthesized and their anti-inflammatory and ulcerogenic activities were evaluated. The pharmacological screening showed that many of these obtained compounds have good anti-inflammatory activities, comparable to the reference drug. The toxicity of the compounds was also assayed via the determination of their LD50 values. The structures of newly synthesized compounds were confirmed by IR, 1H-NMR, MS spectral data and elemental analysis.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269734 | PMC |
| http://dx.doi.org/10.3390/molecules181215051 | DOI Listing |
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