AI Article Synopsis
- The 4:1 supramolecular complex of pyridinium chlorin and [α-SiMo12O40](4-) shows improved photodynamic activity against A549 cancer cells.
- Enhanced singlet oxygen generation contributes to this effectiveness, due to better penetration and localization of chlorin in the cells.
- Confocal microscopy confirms that this complex has a higher cellular uptake and a lower IC50 value, indicating a stronger therapeutic effect than free chlorin alone.
Article Abstract
The 4:1 supramolecular complexed ionic salt between pyridinium chlorin and polyanionic [α-SiMo12O40](4-) exhibits significantly enhanced photodynamic activity against A549 cell lines because of increased singlet oxygen photogeneration through high cellular penetration and localization of the chlorin molecules on the ionic salt into the cancer cell. Confocal laser scanning microscopy images clearly represent a higher uptake and photodynamic effect of this supramolecular complex corresponding to the lower IC50 value compared to the free chlorin.
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| http://dx.doi.org/10.1021/ic401729k | DOI Listing |
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