[To explore the safety testing evaluation index of breast-feeding by hepatitis B-positive mothers].

Objective: To explore the safety testing evaluation index of breast-feeding by hepatitis B-positive mothers.

Methods: HBV DNA from serum and breast milk of 252 hepatitis B-positive mothers were detected with the real-time quantitative PCR.

Results: The total positive rate of HBV DNA in serum had no difference with that in breast milk in hepatitis B-positive mothers (P > 0.05). The positive rate of HBV DNA in serum and breast milk of positive HBeAg were significantly higher than that of hepatitis B-positive mothers with negative HBeAg (P < 0.01).

Conclusion: To detecte HBeAg and HBV DNA in serum and breast milk have important significance for guiding of breast feeding of hepatitis B-positive mothers.