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Blood microvesicles during chronic lymphoproliferative diseases. | LitMetric
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Blood microvesicles during chronic lymphoproliferative diseases.

N P Domnikova T Yu Dolgikh E V Sholenberg E V Vorontsova O B Goreva E V Mel'nikova E A Gorbachenko A Yu Grishanova

Bull Exp Biol Med

Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences; Research Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences; Research Institute of Clinical and Experimental Lymphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia.

Published: November 2013

The levels of CD19 (+) and CD20(+) microvesicles were estimated in the blood of patients with B-cell chronic lymphocytic leukemia and indolent non-Hodgkin lymphoma by flow cytometry method. It was found that the number of B cell microvesicles is several times higher in patients than in volunteers. The level of CD20 (+) microvesicles directly correlated with the number of CD20(+) lymphocytes in patients with chronic lymphoproliferative diseases. Extramedullary tumors cells can be a source of CD19 (+) microvesicles.

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 Source
http://dx.doi.org/10.1007/s10517-013-2286-yDOI Listing

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