Neuroprotective effects of heptapeptide mystixin were studied on the neurons of the olfactory cortex in cultured slices of rat brain. Repeated applications of mystixin in doses of 100 mg/ml on brain slices rapidly reduced the amplitudes of AMPA and NMDA receptor-dependent processes. The effects were reversible and activities of these processes partly restored after washout. The peptide in a dose of 250 mg/ml suppressed epileptic discharges induced by chemical convulsive agent pentylenetetrazole. Thus, heptapeptide mystixin exhibited significant neuroprotective properties.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-013-2277-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neuroprotective effects of heptapeptide mystixin.
Bull Exp Biol Med
November 2013
I. P. Pavlov Institute of Physiology of the Russian Academy of Sciences, Saint-Petersburg, Russia.
Neuroprotective effects of heptapeptide mystixin were studied on the neurons of the olfactory cortex in cultured slices of rat brain. Repeated applications of mystixin in doses of 100 mg/ml on brain slices rapidly reduced the amplitudes of AMPA and NMDA receptor-dependent processes. The effects were reversible and activities of these processes partly restored after washout.
View Article and Find Full Text PDF[Neurotropic effects of heptapeptide mystixin studied on brain tissue sections].
Eksp Klin Farmakol
April 2012
Neurotropic effects of heptapeptide mystixin have been studied on olfactory cortex neurons in rat brain tissue sections. The application of mystixin onto brain section produced a dose-dependent inhibition of AMPA- and NMDA-receptor-dependent processes. The peptide suppressed the activity of inhibitory processes only at small doses (10, 25, and 50 mg/ml) and potentiated these processes at greater doses (100 and 250 mg/ml).
View Article and Find Full Text PDFAnti-inflammatory mystixin peptides inhibit plasma leakage without blocking endothelial gap formation.
J Pharmacol Exp Ther
February 1998
Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, California 94143-0130, USA.
Mystixins are synthetic peptides that inhibit plasma leakage after tissue injury. We sought to determine the mechanism of the antileakage effect of mystixins, with particular reference to the formation of endothelial gaps in postcapillary venules. Intravenous administration of mystixin-7, a prototype heptapeptide (p-anisoyl-Arg-Lys-Leu-Leu-D-Thi-Ile-D-Leu-NH2), decreased Evans blue leakage induced by substance P (5 microg/kg i.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!