Dehydroepiandrosterone sulfate (30 mg/kg) produced a hypotensive effect by preventing stress-induced surge of hypertensive hormone aldosterone in rats after manifold repeated, but not single stress exposure. Both effects were realized via μ-opioid receptors. Thus, μ-opioid mechanism of blockage of aldosterone surge can underlay the hypotensive effects of dehydroepiandrosterone sulfate at least under conditions of manifold repeated exposures.
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| http://dx.doi.org/10.1007/s10517-013-2271-5 | DOI Listing |
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