Objective: This study compared the dosimetry of volumetric-arc therapy (VMAT) and intensity-modulated radiotherapy (IMRT) with a dynamic multileaf collimator using the Monte Carlo algorithm in the treatment of prostate cancer with and without simultaneous integrated boost (SIB) at different energy levels.
Methods: The data of 15 biopsy-proven prostate cancer patients were evaluated. The prescribed dose was 78 Gy to the planning target volume (PTV78) including the prostate and seminal vesicles and 86 Gy (PTV86) in 39 fractions to the intraprostatic lesion, which was delineated by MRI or MR-spectroscopy.
Results: PTV dose homogeneity was better for IMRT than VMAT at all energy levels for both PTV78 and PTV86. Lower rectum doses (V30-V50) were significantly higher with SIB compared with PTV78 plans in both IMRT and VMAT plans at all energy levels. The bladder doses at high dose level (V60-V80) were significantly higher in IMRT plans with SIB at all energy levels compared with PTV78 plans, but no significant difference was observed in VMAT plans. VMAT plans resulted in a significant decrease in the mean monitor units (MUs) for 6, 10, and 15 MV energy levels both in plans with and those without SIB.
Conclusion: Dose escalation to intraprostatic lesions with 86 Gy is safe without causing serious increase in organs at risk (OARs) doses. VMAT is advantageous in sparing OARs and requiring less MU than IMRT.
Advances In Knowledge: VMAT with SIB to intraprostatic lesion is a feasible method in treating prostate cancer. Additionally, no dosimetric advantage of higher energy is observed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064542 | PMC |
| http://dx.doi.org/10.1259/bjr.20130617 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synergistic activity of Pitstop-2 and 1,6-hexanediol in aggressive human lung cancer cells.
Discov Nano
January 2025
Institute of Physiology II, University of Münster, Robert-Koch-Str. 27b, 48149, Münster, Germany.
Metastatic cancer cells undergo metabolic reprogramming, which involves changes in the metabolic fluxes, including endocytosis, nucleocytoplasmic transport, and mitochondrial metabolism, to satisfy their massive demands for energy, cell division, and proliferation compared to normal cells. We have previously demonstrated the ability of two different types of compounds to interfere with linchpins of metabolic reprogramming, Pitstop-2 and 1,6-hexanediol (1,6-HD). 1,6-HD disrupts glycolysis enzymes and mitochondrial function, enhancing reactive oxygen species production and reducing cellular ATP levels, while Pitstop-2 impedes clathrin-mediated endocytosis and small GTPases activity.
View Article and Find Full Text PDFThe divide expand consolidate scheme for unrestricted second order Møller-Plesset perturbation theory ground state energies.
J Chem Phys
January 2025
Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, Tennessee 37830, USA.
The linear scaling divide-expand-consolidate (DEC) framework is expanded to include unrestricted Hartree-Fock references. By partitioning the orbital space and employing local molecular orbitals, the full molecular calculation can be performed as independent calculations on individual fragments, making the method well-suited for massively parallel implementations. This approach also incorporates error control through the fragment optimization threshold (FOT), which maintains precision and consistency throughout the calculations.
View Article and Find Full Text PDFMultifunctional applications enabled by tunable multi-emission and ultra-broadband VIS-NIR luminescence energy transfer in Sn/Mn-doped lead-free Zn-based metal halides.
Mater Horiz
January 2025
School of Physical Science and Technology, School of Chemistry and Chemical Engineering, State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, and School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China.
Metal halides are widely applied in solid-state lighting (SSL), optoelectronic devices, information encryption, and near-infrared (NIR) detection due to their superior photoelectric properties and tunable emission. However, single-component phosphors that can be efficiently excited by light-emitting diode (LED) chips and cover both the visible (VIS) and NIR emission regions are still very rare. To address this issue, (TPA)ZnBr:Sn/Mn (TPA = [(CHCHCH)N]) phosphors were synthesized by using the solvent evaporation method.
View Article and Find Full Text PDFEnergy Aggregation for Illuminating Upconversion Multicolor Emission Based on Ho Ions.
ACS Appl Mater Interfaces
January 2025
School of Materials Science& Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Lanthanide-doped upconversion luminescent nanoparticles (UCNPs) have garnered extensive attention due to their notable anti-Stokes shifts and superior photostability. Notably, Ho-based UCNPs present a complex energy level configuration, which poses challenges in augmenting their luminescence efficiency. Herein, a rational design strategy was used to enhance the upconversion luminescence intensity of Ho ions by improving the photon absorption ability and energy utilization efficiency.
View Article and Find Full Text PDFThe year of a leaf: Tracking the fate of leaf litter and its nutrients during aquatic decomposition and consumption.
Ecology
January 2025
Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland.
Temperate streams are subsidized by inputs of leaf litter peaking in fall. Yet, stream communities decompose dead leaves and integrate their energy into the aquatic food web throughout the whole year. Most studies investigating stream decomposition largely overlook long-term trajectories, which must be understood for an appropriate temporal upscaling of ecosystem processes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!